Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona.
Endoscopia Gastrointestinal/Motilidad, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Am J Gastroenterol. 2020 Jul;115(7):1125-1128. doi: 10.14309/ajg.0000000000000682.
Normal response to multiple rapid swallows (MRS) during high-resolution esophageal manometry is deglutitive inhibition; opioids may interfere with this. The aim of this study was to evaluate the response to MRS in patients on opioids, not on opioids, and healthy controls.
Response to MRS was evaluated for complete vs impaired inhibition in 72 chronic opioid users, 100 patients not on opioids, and 24 healthy controls.
Impaired deglutitive inhibition was significantly more frequent in chronic opioid users compared with patients not on opioids and healthy controls (54% vs 14% vs 0%; P < 0.0001).
Impaired deglutitive inhibition during MRS is frequent in opioid users, supporting that opioids interfere with esophageal inhibitory signals.
在高分辨率食管测压期间，对多次快速吞咽（MRS）的正常反应是吞咽抑制；阿片类药物可能会干扰这种反应。本研究旨在评估 MRS 在使用阿片类药物、未使用阿片类药物和健康对照组患者中的反应。
评估 72 例慢性阿片类药物使用者、100 例未使用阿片类药物患者和 24 例健康对照者对 MRS 的反应，以确定完全抑制与抑制受损。
与未使用阿片类药物的患者和健康对照组相比，慢性阿片类药物使用者的吞咽抑制受损更为频繁（54%比 14%比 0%；P<0.0001）。
在 MRS 期间吞咽抑制受损在阿片类药物使用者中很常见，这支持阿片类药物干扰食管抑制信号的观点。
