Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and.
Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.
Am J Dermatopathol. 2021 Feb 1;43(2):119-136. doi: 10.1097/DAD.0000000000001706.
Intravascular proliferations of the skin are clinically heterogeneous and may present with a wide range of clinical features, including violaceous papules, nodules, plaques, or other unspecific cutaneous lesions. Histopathologically, these conditions are characterized by proliferation of different cell types within the lumina of dermal vessels and endothelial cell hyperplasia. Immunohistochemistry is the best tool to identify the nature of the intravascular proliferating cells and the type of involved vessel. In this review, we analyzed the clinicopathologic and immunohistochemical characteristics of intravascular large cell lymphoma, T-cell and natural killer-cell intravascular large cell lymphoma, intralymphatic variant of CD30+ cutaneous lymphoproliferative disorders, benign atypical intralymphatic CD30+ T-cell proliferation, reactive angioendotheliomatosis, intralymphatic histiocytosis, papillary intralymphatic angioendothelioma or Dabska tumor, glomeruloid hemangioma, papillary hemangioma, intravascular papillary endothelial hyperplasia or Masson phenomenon, and the intralymphatic involvement of Merkel cell carcinoma, cutaneous metastases, and cutaneous angiosarcoma.
皮肤脉管内增生在临床上具有异质性，可能表现出广泛的临床特征，包括紫色丘疹、结节、斑块或其他非特异性皮肤损害。组织病理学上，这些病变的特征是真皮血管管腔和内皮细胞增生中不同细胞类型的增殖。免疫组织化学是识别脉管内增生细胞的性质和受累血管类型的最佳工具。在这篇综述中，我们分析了血管内大细胞淋巴瘤、T 细胞和自然杀伤细胞血管内大细胞淋巴瘤、CD30+皮肤淋巴增生性疾病的淋巴管内变异型、良性非典型淋巴管内 CD30+T 细胞增生、反应性血管内皮细胞瘤、淋巴管内组织细胞增生、乳头状淋巴管内血管内皮瘤或 Dabska 瘤、血管球样血管瘤、乳头状血管瘤、血管内乳头状内皮细胞增生或 Masson 现象，以及 Merkel 细胞癌、皮肤转移和皮肤血管肉瘤的淋巴管内累及。
