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三叶瓣生物瓣突发三瓣叶撕脱

Trifecta Bioprosthesis Sudden-Onset Three-Leaflet Detachment.

机构信息

Cardiac Surgery Department, Hospital Universitario Moncloa, Madrid, Spain.

Cardiac Surgery Department, Hospital Universitario Moncloa, Madrid, Spain.

出版信息

Ann Thorac Surg. 2021 Feb;111(2):e127-e128. doi: 10.1016/j.athoracsur.2020.05.065. Epub 2020 Jun 30.

DOI:10.1016/j.athoracsur.2020.05.065
PMID:32619616
Abstract

Acute bioprosthesis failure is an uncommon event that may require urgent surgery. This is even less frequent when it is not associated with endocarditis, thrombus formation, or structural valve deterioration. We describe an acute complete detachment of the 3 leaflets of a Trifecta tissue valve 6 years after implantation in a patient who suddenly experienced strong chest pain with severe dyspnea. In the operating room, total detachment of the 3 leaflets from the scalloped cuff and from 1 of the cusps was observed. No signs of endocarditis or leaflet calcifications were found.

摘要

急性生物假体失效是一种罕见的事件,可能需要紧急手术。如果它不与心内膜炎、血栓形成或结构性瓣膜恶化有关,这种情况就更少见了。我们描述了一名患者在植入 Trifecta 组织瓣 6 年后突然出现剧烈胸痛和严重呼吸困难,导致 3 个瓣叶急性完全从扇形袖口和 1 个瓣叶游离。在手术室中,观察到 3 个瓣叶从扇形袖口和 1 个瓣叶游离。未发现心内膜炎或瓣叶钙化的迹象。

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Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model.α-半乳糖抗原、抗体反应与心脏瓣膜生物假体钙化的相关性:应用α-半乳糖敲除小鼠动物模型获得的实验证据。
Front Immunol. 2023 Jun 21;14:1210098. doi: 10.3389/fimmu.2023.1210098. eCollection 2023.