University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390, USA; Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA.
Clin Liver Dis. 2020 Aug;24(3):521-534. doi: 10.1016/j.cld.2020.04.004. Epub 2020 May 26.
Acute on chronic liver failure (ACLF) is an inflammation-based disorder that occurs in patients with underlying liver disease and is characterized by hepatic and extrahepatic organ failure. Morbidity and mortality are high in patients with ACLF, and therefore prevention and early identification are critical to improve outcome. The purpose of this article is to define ACLF, describe ways to identify the expected outcome of ACLF after development, and illustrate interventions to prevent it and when it is not preventable reduce associated morbidity and mortality.
急性慢性肝衰竭（ACLF）是一种以炎症为基础的疾病，发生于潜在肝脏疾病患者中，其特征为肝和肝外器官衰竭。ACLF 患者的发病率和死亡率都很高，因此预防和早期识别对于改善预后至关重要。本文旨在定义 ACLF，描述确定 ACLF 发生后预期结果的方法，并说明预防 ACLF 的干预措施，以及当 ACLF 无法预防时如何降低其相关发病率和死亡率。
