英国血友病患者中HIV抗体的流行情况：第二次调查。英国血友病中心主任艾滋病研究小组与英国血友病中心主任合作开展。

Prevalence of antibody to HIV in haemophiliacs in the United Kingdom: a second survey. AIDS Group of the United Kingdom Haemophilia Centre Directors with the co-operation of the United Kingdom Haemophilia Centre Directors.

出版信息

Clin Lab Haematol. 1988;10(2):187-91. doi: 10.1111/j.1365-2257.1988.tb01170.x.

DOI:10.1111/j.1365-2257.1988.tb01170.x

PMID:3262033

Abstract

A survey of prevalence of anti-HIV in patients with haemophilia A, B or von Willebrand's disease in the UK was carried out in July-August 1986 and 86 of the 109 centres contacted sent in information. Of 2330 haemophilia A patients, 955 (41%) were found to be anti-HIV positive; 26 (6%) out of 401 haemophilia B patients were found positive. The prevalence in severely affected patients was greater-59% in haemophilia A patients tested and 11% in haemophilia B patients tested. Comparison with a similar survey carried out by the Haemophilia Centre Directors in 1985 showed that 38 patients with haemophilia A and seven with haemophilia B had seroconverted since the 1985 survey. In only one of the haemophilia A patients was it possible to say that this seroconversion had probably been caused by heated concentrate.

摘要

1986年7月至8月，英国对甲型、乙型血友病或血管性血友病患者进行了抗HIV感染率调查，109个联系中心中有86个提供了信息。在2330名甲型血友病患者中，955名（41%）抗HIV检测呈阳性；401名乙型血友病患者中有26名（6%）检测呈阳性。重症患者的感染率更高——接受检测的甲型血友病患者中为59%，乙型血友病患者中为11%。与血友病中心主任在1985年进行的类似调查相比，自1985年调查以来，有38名甲型血友病患者和7名乙型血友病患者发生了血清转化。在仅有的一名甲型血友病患者中，可以确定这种血清转化可能是由加热浓缩物引起的。