筛查腹主动脉瘤患者的肺癌患病率和发病率。

Coprevalence and Incidence of Lung Cancer in Patients Screened for Abdominal Aortic Aneurysm.

机构信息

First Department of Medicine (Cardiology), University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, European Centre for AngioScience (ECAS), Mannheim, Germany

DZHK (German Centre for Cardiovascular Research) partner site Heidelberg/Mannheim, Mannheim, Germany.

出版信息

Anticancer Res. 2020 Jul;40(7):4137-4145. doi: 10.21873/anticanres.14413.

DOI:10.21873/anticanres.14413

PMID:32620663

Abstract

BACKGROUND/AIM: Lung diseases are common in patients with abdominal aortic aneurysms (AAA). This study evaluates the prevalence of lung cancer (LC) in high-risk patients screened for AAA.

PATIENTS AND METHODS

Six hundred and one male patients (≥65 years of age, cardiovascular high-risk profile) were enrolled and followed prospectively over a median of 16.5 months.

RESULTS

In 29 patients (4.8%) LC and in another 50 patients (8.3%) AAA were found. The prevalence of LC among patients with AAA was even higher (9 of 50, 18.0%). Twenty-one patients had an initial diagnosis of LC, with an incidence of 12.0% (6 of 50) in patients with AAA. During follow-up, 14 of 70 patients with AAA and/ or LC (20.0%) deceased. The highest mortality was found in patients with LC only (8 of 20, 40.0%), followed by patients with both AAA and LC (3 of 9, 33.3%), while patients with AAA only had the lowest mortality rate (3 of 41, 7.3%).

CONCLUSION

In patients with a high cardiovascular risk profile, a high prevalence of both AAA and LC were found, whereby the prognosis is largely determined by the LC. Therefore, LC is of particular importance in the setting of screening and surveillance of AAA.

摘要

背景/目的：肺部疾病在腹主动脉瘤（AAA）患者中很常见。本研究评估了在接受 AAA 筛查的高危患者中肺癌（LC）的患病率。

患者和方法

纳入了 601 名男性患者（年龄≥65 岁，心血管高危人群），并对他们进行了中位时间为 16.5 个月的前瞻性随访。

结果

在 29 名患者（4.8%）中发现了 LC，在另外 50 名患者（8.3%）中发现了 AAA。在患有 AAA 的患者中，LC 的患病率甚至更高（9/50，18.0%）。21 名患者最初被诊断为 LC，其中 6 名（6/50）在患有 AAA 的患者中发生。在随访期间，70 名患有 AAA 和/或 LC 的患者中有 14 名（20.0%）死亡。LC 患者的死亡率最高（8/20，40.0%），其次是同时患有 AAA 和 LC 的患者（3/9，33.3%），而仅患有 AAA 的患者死亡率最低（3/41，7.3%）。