棒酸9-(2-氨乙烯基硫基)-9-脱氧衍生物的合成及β-内酰胺酶抑制活性
Synthesis and beta-lactamase inhibitory activity of 9-(2-amidoethenylthio)-9-deoxy derivatives of clavulanic acid.
作者信息
Brooks G, Coleman K, Davies J S, Hunter P A
机构信息
Beecham Pharmaceuticals Research Division, Chemotherapeutic Research Centre, Betchworth, Surrey, England.
出版信息
J Antibiot (Tokyo). 1988 Jul;41(7):892-8. doi: 10.7164/antibiotics.41.892.
PMID:3262103
Abstract
The reaction of activated derivatives of clavulanic acid with substituted amidoethenyl thiolates to give 9-(2-amidoethenylthio)-9-deoxy derivatives is described; the antibacterial/synergistic and beta-lactamase inhibitory activities of the thioethers and their corresponding sulfoxides and sulfones are compared.
摘要
描述了棒酸的活化衍生物与取代的酰胺乙烯硫醇盐反应生成9-(2-酰胺乙烯硫基)-9-脱氧衍生物的过程；比较了硫醚及其相应的亚砜和砜的抗菌/协同和β-内酰胺酶抑制活性。
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