Tan Yuan-De
Institute of Personalized Medicine, PENN State University, Hershey College of Medicine, PA, USA.
Genomics. 2020 Nov;112(6):3943-3950. doi: 10.1016/j.ygeno.2020.06.034. Epub 2020 Jul 1.
Following Hardy-Weinberg disequilibrium (HWD) occurring at a single locus and linkage disequilibrium (LD) between two loci in generations, we here proposed the third genetic disequilibrium in a population: recombination disequilibrium (RD). RD is a measurement of crossover interference among multiple loci in a random mating population. In natural populations besides recombination interference, RD may also be due to selection, mutation, gene conversion, drift and/or migration. Therefore, similarly to LD, RD will also reflect the history of natural selection and mutation. In breeding populations, RD purely results from recombination interference and hence can be used to build or evaluate and correct a linkage map. Practical examples from F, testcross and human populations indeed demonstrate that RD is useful for measuring recombination interference between two short intervals and evaluating linkage maps. As with LD, RD will be important for studying genetic mapping, association of haplotypes with disease, plant breading and population history.
继一代中单个位点出现哈迪-温伯格不平衡（HWD）以及两个位点间出现连锁不平衡（LD）之后，我们在此提出群体中的第三种遗传不平衡：重组不平衡（RD）。RD是对随机交配群体中多个位点间交叉干扰的一种度量。在自然群体中，除了重组干扰外，RD还可能归因于选择、突变、基因转换、漂变和/或迁移。因此，与LD类似，RD也将反映自然选择和突变的历史。在育种群体中，RD纯粹由重组干扰导致，因此可用于构建或评估及校正连锁图谱。来自F1测交群体和人类群体的实际例子确实表明，RD对于测量两个短区间之间的重组干扰以及评估连锁图谱是有用的。与LD一样，RD对于研究遗传作图、单倍型与疾病的关联、植物育种和群体历史都将具有重要意义。
