Sunnybrook Health Sciences Centre, Toronto, Canada.
University of Toronto, Toronto, Ontario, Canada.
Syst Rev. 2020 Jul 4;9(1):154. doi: 10.1186/s13643-020-01358-x.
Prediction of long-term neurodevelopmental outcomes remains an elusive goal for neonatology. Clinical and socioeconomic markers have not proven to be adequately reliable. The limitation in prognostication includes those term and late-preterm infants born with neonatal encephalopathy. The General Movements Assessment tool by Prechtl has demonstrated reliability for identifying infants at risk for neuromotor impairment. This tool is non-invasive and cost-effective. The purpose of this study is to identify the published literature on how this tool applies to the prediction of cerebral palsy in term and late-preterm infants diagnosed with neonatal encephalopathy and so detect the research gaps.
We will conduct a systematic scoping review for data on sensitivity, specificity, positive, and negative predictive value and describe the strengths and limitations of the results. This review will consider studies that included infants more than or equal to 34 + 0 weeks gestational age, diagnosed with neonatal encephalopathy, with a General Movements Assessment done between birth to six months of life and an assessment for cerebral palsy by at least 2 years of age. Experimental and quasi-experimental study designs including randomized controlled trials, non-randomized controlled trials, before and after studies, interrupted time-series studies and systematic reviews will be considered. Case reports, case series, case control, and cross-sectional studies will be included. Text, opinion papers, and animal studies will not be considered for inclusion in this scoping review as this is a highly specific and medical topic. Studies in the English language only will be considered. Studies published from at least 1970 will be included as this is around the time when the General Movements Assessment was first introduced in neonatology as a potential predictor of neuromotor outcomes. We will search five databases (MEDLINE, Embase, PsychINFO, Scopus, and CINAHL). Two reviewers will conduct all screening and data extraction independently. The articles will be categorized according to key findings and a critical appraisal performed.
The results of this review will guide future research to improve early identification and timely intervention in infants with neonatal encephalopathy at risk of neuromotor impairment.
Title registration with Joanna Briggs Institute https://joannabriggs.org/ebp/systematic_review_register .
预测长期神经发育结局仍然是新生儿学难以实现的目标。临床和社会经济标志物并未被证明具有足够的可靠性。预后的局限性包括那些足月和晚期早产儿出生时患有新生儿脑病。Prechtl 的一般运动评估工具已被证明可用于识别有神经运动障碍风险的婴儿。该工具无创且具有成本效益。本研究的目的是确定发表的文献，了解该工具如何应用于预测诊断为新生儿脑病的足月和晚期早产儿脑瘫，并发现研究空白。
我们将对数据进行系统的范围综述，以评估敏感性、特异性、阳性和阴性预测值，并描述结果的优势和局限性。本综述将考虑包括至少 34+0 周胎龄、诊断为新生儿脑病、出生至 6 个月期间进行一般运动评估且至少在 2 岁时进行脑瘫评估的婴儿的研究。将考虑实验和准实验研究设计，包括随机对照试验、非随机对照试验、前后研究、中断时间序列研究和系统评价。将包括病例报告、病例系列、病例对照和横断面研究。本文将不考虑纳入范围综述的文本、意见论文和动物研究，因为这是一个高度特定和医学主题。仅考虑英语语言的研究。将包括至少从 1970 年开始发表的研究，因为这是一般运动评估首次作为神经运动结局潜在预测指标引入新生儿学的时间。我们将在五个数据库（MEDLINE、Embase、PsychINFO、Scopus 和 CINAHL）中进行搜索。两名评审员将独立进行所有筛选和数据提取。文章将根据关键发现进行分类，并进行批判性评价。
本综述的结果将指导未来的研究，以改善有神经运动障碍风险的新生儿脑病婴儿的早期识别和及时干预。
与 Joanna Briggs 研究所的标题注册 https://joannabriggs.org/ebp/systematic_review_register。
