钙拮抗剂对钾离子去极化时离体骨骼肌氧消耗的抑制作用。

Depressing effects of calcium antagonists on oxygen consumption in isolated skeletal muscle during potassium depolarization.

作者信息

Barnes W S

机构信息

Department of Health, Texas A & M University, College Station 77843.

出版信息

Can J Physiol Pharmacol. 1988 Jun;66(6):836-40. doi: 10.1139/y88-134.

DOI:10.1139/y88-134

PMID:3262403

Abstract

The effects of two Ca2+-antagonizing drugs, dantrolene sodium (DAN) and TMB-8, on subcontracture, K+-induced increased oxygen consumption were studied in isolated frog sartorius muscles. Incubation in Ringer's solution +18 mM KCl caused a marked increase in averaged resting oxygen uptake (52.8 +/- 4.1 to 278.2 +/- 20.0 mm3.g-1.h-1). Incubation in Ringer's +18 mM KCl containing either 0.116 mM TMB-8 or 0.035 mM DAN resulted in a significant reduction in the averaged metabolic response (264.4 +/- 30.8 (control) vs. 142.3 +/- 19.0 (TMB-8) vs. 72.2 +/- 3.4 (DAN]. The results suggest that the enhanced metabolic rate observed upon elevating extracellular [K+] to just below contracture levels is due to increased intracellular Ca2+ release.

摘要

在离体青蛙缝匠肌中研究了两种钙拮抗药物——丹曲林钠（DAN）和TMB - 8对亚挛缩、钾离子诱导的耗氧量增加的影响。在林格氏液+18 mM氯化钾中孵育导致平均静息氧摄取量显著增加（从52.8±4.1增至278.2±20.0立方毫米·克⁻¹·小时⁻¹）。在含有0.116 mM TMB - 8或0.035 mM DAN的林格氏液+18 mM氯化钾中孵育导致平均代谢反应显著降低（对照组为264.4±30.8，TMB - 8组为142.3±19.0，DAN组为72.2±3.4）。结果表明，将细胞外[K⁺]升高至略低于挛缩水平时观察到的代谢率增强是由于细胞内钙释放增加所致。