24R,25-二羟基维生素D3在实验性肾功能不全中的作用

Effect of 24R,25-dihydroxyvitamin D3 in experimental renal insufficiency.

作者信息

Katoh T, Maeda Y, Yamato H, Hirai T, Fujii T, Matsunaga K, Kodaira T, Konai Y

机构信息

Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd, Tokyo, Japan.

出版信息

J Int Med Res. 1988 Jul-Aug;16(4):294-9. doi: 10.1177/030006058801600407.

DOI:10.1177/030006058801600407

PMID:3262544

Abstract

This placebo-controlled study in JCL-Wistar rats showed that 100 micrograms/kg 24R,25-dihydroxyvitamin D3, when given for 12 days consecutively, restored immune function which had deteriorated following aminonucleoside-induced nephrosis. Urinary creatinine excretion in five-sixths nephrectomized rats was also shown to be increased by 10 micrograms/kg 24R,25-dihydroxyvitamin D3. Hypophosphataemic effects in both these cases of experimentally-induced renal insufficiency was also shown following administration of 24R,25-dihydroxyvitamin D3.

摘要

这项针对JCL-威斯塔大鼠的安慰剂对照研究表明，连续12天给予100微克/千克的24R,25-二羟基维生素D3，可恢复因氨基核苷诱导的肾病而恶化的免疫功能。同时还表明，给予10微克/千克的24R,25-二羟基维生素D3可使六分之五肾切除大鼠的尿肌酐排泄增加。在这两种实验性诱导的肾功能不全病例中，给予24R,25-二羟基维生素D3后也出现了低磷血症效应。