24R,25-二羟基维生素D3对实验性糖尿病大鼠的影响。

Effect of 24R,25-dihydroxyvitamin D3 in experimental diabetic rats.

作者信息

Katoh T, Maeda Y, Yamato H, Hirai T, Fujii T, Yoshino F, Kodaira T, Konai Y

机构信息

Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd, Tokyo, Japan.

出版信息

J Int Med Res. 1988 Jul-Aug;16(4):300-4. doi: 10.1177/030006058801600408.

DOI:10.1177/030006058801600408

PMID:3262545

Abstract

The results are presented of a controlled study in male Wistar rats into the effects of 24R,25-dihydroxyvitamin D3 on blood glucose levels, bone calcium content and ADP-induced platelet aggregation in streptozocin-induced diabetes mellitus. Blood glucose levels were shown to be decreased by 10 micrograms/kg 24R,25-dihydroxyvitamin D3. The reduced bone calcium content associated with diabetes mellitus was returned to normal levels with both 1 and 10 micrograms/kg 24R,25-dihydroxyvitamin D3. It was also shown to exhibit dose-dependent anti-platelet activity. The data suggest that 24R,25-dihydroxyvitamin D3 might have potential as a mild therapeutic agent in the treatment of osteoporosis and platelet hyperactivity associated with diabetes mellitus.

摘要

本文呈现了一项针对雄性Wistar大鼠的对照研究结果，该研究旨在探究24R,25-二羟基维生素D3对链脲佐菌素诱导的糖尿病大鼠血糖水平、骨钙含量及ADP诱导的血小板聚集的影响。结果显示，给予10微克/千克的24R,25-二羟基维生素D3可使血糖水平降低。糖尿病相关的骨钙含量降低在给予1微克/千克和10微克/千克的24R,25-二羟基维生素D3后恢复至正常水平。同时还表明其具有剂量依赖性的抗血小板活性。这些数据表明，24R,25-二羟基维生素D3可能具有作为温和治疗剂治疗与糖尿病相关的骨质疏松和血小板活性亢进的潜力。