类风湿关节炎和系统性红斑狼疮患者血清中RHP及游离C1q的水平。
Serum levels of RHP and of unbound C1q in rheumatoid arthritis and systemic lupus erythematosus.
作者信息
Rosano C L, Parhami N, Hechemy K E, Hurwitz C
机构信息
Research Service, Veterans Administration Medical Center, Albany, New York.
出版信息
Inflammation. 1988 Aug;12(4):351-60. doi: 10.1007/BF00915770.
PMID:3262584
Abstract
RHP is a recently described serum protein which inhibits a number of physiologic functions of C1q unbound to C1r2 x C1s2. In this report we show that sera from patients with rheumatoid arthritis contained elevated levels of RHP and of unbound C1q. Sera from patients with systemic lupus erythematosus contained normal levels of RHP and were characterized by deficits of C1q required to form C1 from existing levels of C1r and C1s.
摘要
RHP是一种最近被描述的血清蛋白，它能抑制未与C1r2×C1s2结合的C1q的多种生理功能。在本报告中，我们表明类风湿性关节炎患者的血清中RHP和未结合的C1q水平升高。系统性红斑狼疮患者的血清中RHP水平正常，其特征是从现有水平的C1r和C1s形成C1所需的C1q缺乏。
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