Rychen Guido, Aquilina Gabriele, Azimonti Giovanna, Bampidis Vasileios, Bastos Maria de Lourdes, Bories Georges, Chesson Andrew, Cocconcelli Pier Sandro, Flachowsky Gerhard, Gropp Jürgen, Kolar Boris, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Mantovani Alberto, Mayo Baltasar, Ramos Fernando, Saarela Maria, Villa Roberto Edoardo, Wester Pieter, Costa Lucio, Dierick Noël, Glandorf Boet, Herman Lieve, Kärenlampi Sirpa, Leng Lubomir, Tebbe Christoph, Aguilera Jaime, Manini Paola, Tarrés-Call Jordi, Wallace Robert John
EFSA J. 2018 Jul 12;16(7):e05337. doi: 10.2903/j.efsa.2018.5337. eCollection 2018 Jul.
The European Commission asked EFSA for an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a riboflavin-based additive (minimum 80%) produced by a genetically modified strain of (■■■■■). It is intended to be used in feed for all animal species and categories. The additive under assessment does not give rise to safety concerns on the genetic modification of the production strain. The additive contains 80% of riboflavin (vitamin B) and 20% of spent growth medium. The additive is safe for target animals with a wide margin of safety. The use of riboflavin 80% produced by ■■■■■ in animal nutrition does not represent a safety concern for consumers. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) cannot draw a final conclusion on the risk posed for the user by inhalation of riboflavin produced by ■■■■■ and on the potential to be irritant to skin or eyes. The product under assessment is not a skin sensitiser; however, riboflavin is a known photosensitiser. The use of riboflavin produced by ■■■■■ in animal nutrition does not pose a risk to the environment. The additive is regarded as an effective source of riboflavin in covering the animal's requirement when administered via feed. The FEEDAP Panel made recommendations on the description of the additive.
欧盟委员会要求欧洲食品安全局就一种由（■■■■■）转基因菌株生产的核黄素基添加剂（最低80%）对目标动物、消费者、使用者和环境的安全性以及其功效发表意见。该添加剂拟用于所有动物种类和类别的饲料。所评估的添加剂在生产菌株的基因改造方面不存在安全问题。该添加剂含有80%的核黄素（维生素B）和20%的废弃生长培养基。该添加剂对目标动物具有很高的安全性。在动物营养中使用由■■■■■生产的80%核黄素对消费者不构成安全问题。动物饲料添加剂和产品或物质专家小组（FEEDAP）无法就吸入由■■■■■生产的核黄素对使用者造成的风险以及对皮肤或眼睛的潜在刺激性得出最终结论。所评估的产品不是皮肤致敏剂；然而，核黄素是一种已知的光敏剂。在动物营养中使用由■■■■■生产的核黄素对环境不构成风险。当通过饲料给药时，该添加剂被视为满足动物核黄素需求的有效来源。FEEDAP小组就该添加剂的描述提出了建议。
