Bucy R P, Chen C L, Cihak J, Lösch U, Cooper M D
Department of Pathology, University of Alabama School of Medicine, Birmingham 35294.
J Immunol. 1988 Oct 1;141(7):2200-5.
A panel of murine mAb specific for the chicken homologues of the CD3, CD4, CD8, TCR gamma delta, and TCR alpha beta has been used to study the distribution of T cells expressing these markers in sections of chicken lymphoid tissues. These studies have revealed that the T cells possessing the two classes of TCR occupy distinct histologic microenvironments. The TCR1+ cells (gamma delta TCR homologue) are localized preferentially in the splenic sinusoids and the intestinal epithelium, where most of them express the CD8 homologue. The TCR2+ cells (alpha beta TCR homologue), a majority of which express the CD4 homologue, are found primarily in the splenic periarteriolar sheath and the lamina propria of the intestine. The frequency and distribution of the two classes of T cells in the thymus is also unique. The different tissue homing patterns of the TCR1 and TCR2 cells suggest that they represent separate lineages of T cells with distinctive physiologic roles.
一组针对鸡的CD3、CD4、CD8、TCRγδ和TCRαβ同源物的鼠单克隆抗体已被用于研究表达这些标志物的T细胞在鸡淋巴组织切片中的分布。这些研究表明，拥有两类TCR的T细胞占据不同的组织学微环境。TCR1+细胞（γδTCR同源物）优先定位于脾血窦和肠上皮，其中大多数表达CD8同源物。TCR2+细胞（αβTCR同源物），其中大多数表达CD4同源物，主要存在于脾动脉周围鞘和肠固有层。两类T细胞在胸腺中的频率和分布也很独特。TCR1和TCR2细胞不同的组织归巢模式表明它们代表具有独特生理作用的不同T细胞谱系。
