Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences/the Second School of Clinical Medicine, Southern Medical University, Guangzhou 510080, China.
Aier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye Hospital, Guangzhou 510199, China.
J Diabetes Res. 2020 Jun 13;2020:9705786. doi: 10.1155/2020/9705786. eCollection 2020.
To evaluate the impact of restoration of foveal bulge (FB) in optical coherence tomography (OCT) images on visual acuity after resolution of diabetic macular edema with coexisting serous retinal detachment (SRD-DME).
A total of 52 eyes with resolved SRD-DME and an intact ellipsoid zone at the central fovea were included. All eyes underwent best-corrected visual acuity (BCVA) examination and OCT scanning at baseline and follow-up visits (1, 3, and 6 months). The eyes were divided into two groups according to the presence of FB at 6 months. BCVA, central foveal thickness (CFT), height of SRD (SRDH), outer nuclear layer (ONL) thickness, photoreceptor inner segment (PIS), and outer segment (POS) length were compared between the two groups.
A FB was found in 25 of 52 (48%) eyes at 6 months. The FB (+) group had lower SRDH at baseline, and better BCVA, longer POS length at 6 months (all < 0.05). There was no significant difference in the CFT, ONL thickness, and PIS length at 6 months between the two groups (all > 0.05). More eyes in the FB (+) group had complete SRD resolution at 1 month ( = 0.009) and 3 months ( = 0.012). Eyes with complete SRD resolution at 1 month ( = 0.009) or 3 months ( = 0.012) were more likely to have a FB at 6 months.
The Presence of the FB is associated with better BCVA after resolution of SRD-DME. Eyes with lower baseline SRDH or faster SRD resolution are more likely to have a FB at 6 months.
评估在伴有浆液性视网膜脱离（SRD-DME）的糖尿病性黄斑水肿消退后，光学相干断层扫描（OCT）图像中黄斑中心凹隆突（FB）的恢复对视力的影响。
共纳入 52 只眼，这些眼均存在 SRD-DME 消退和中央凹区完整的椭圆体带。所有眼在基线和随访（1、3 和 6 个月）时均接受最佳矫正视力（BCVA）检查和 OCT 扫描。根据 6 个月时是否存在 FB，将这些眼分为两组。比较两组间的 BCVA、中央凹视网膜厚度（CFT）、SRD 高度（SRDH）、外核层（ONL）厚度、光感受器内节（PIS）和外节（POS）长度。
在 52 只眼中，有 25 只（48%）在 6 个月时存在 FB。FB（+）组在基线时的 SRDH 较低，而在 6 个月时的 BCVA 更好，POS 长度更长（均 < 0.05）。两组在 6 个月时的 CFT、ONL 厚度和 PIS 长度均无显著差异（均 > 0.05）。在 1 个月（ = 0.009）和 3 个月（ = 0.012）时，更多 FB（+）组的眼完全消退 SRD。在 1 个月（ = 0.009）或 3 个月（ = 0.012）时完全消退 SRD 的眼更有可能在 6 个月时存在 FB。
SRD-DME 消退后 FB 的存在与更好的 BCVA 相关。基线时 SRDH 较低或 SRD 消退较快的眼在 6 个月时更有可能存在 FB。
