Interdisciplinary Science and Technology Research Academy, Abeda Inamdar Senior College, University of Pune, 2390-B, K.B. Hidayatullah Road, Pune 411001, India.
Department of Chemistry, Abeda Inamdar Senior College, University of Pune, 2390-B, K.B. Hidayatullah Road, Pune 411001, India.
Anticancer Agents Med Chem. 2021;21(5):558-566. doi: 10.2174/1871520620666200705215722.
Chalcones are structurally simple compounds that are easily accessible by synthetic methods. Heterocyclic chalcones have gained the interest of scientists due to their diverse biological activities. The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications dealing with this topic warrants an up-to-date compilation.
Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as common web-based literature searching tools. Pertinent and current literature was covered from 2015/2016 to 2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones are summarized.
Simply prepared chalcones have emerged over the last years with promising antitumor activities. Among them, there are a considerable number of tubulin polymerization inhibitors. But there are also new chalcones targeting special enzymes such as histone deacetylases or with DNA-binding properties.
This review provides a summary of recent heterocyclic chalcone derivatives with distinct antitumor activities.
查耳酮是结构简单的化合物，可通过合成方法轻松获得。由于具有多种生物活性，杂环查耳酮引起了科学家的兴趣。杂环查耳酮具有显著的抗肿瘤活性，越来越多的相关出版物证明了这一点，因此有必要对此进行最新的综述。
使用 Pubmed 和 Scifinder 等常用的网络文献检索工具，搜索具有抗肿瘤活性的杂环查耳酮。综述涵盖了 2015/2016 年至 2019 年的相关和最新文献。总结了具有抗肿瘤活性的杂环查耳酮的化学结构、生物活性和作用机制。
近年来，简单制备的查耳酮具有良好的抗肿瘤活性。其中，有相当数量的微管蛋白聚合抑制剂。但也有一些新的查耳酮针对特殊酶，如组蛋白去乙酰化酶或具有 DNA 结合特性。
本文综述了近年来具有明显抗肿瘤活性的杂环查耳酮衍生物。
