铑（III）催化的8-甲基喹啉的C（sp）-H乙酰氧基化反应
Rh(III)-Catalyzed C(sp)-H Acetoxylation of 8-Methylquinolines.
作者信息
Chen You-Ke, Kang Yan-Shang, Xu Hua-Jin, Zhang Ping, Zhao Jing, Li Tiantian, Sun Wei-Yin, Lu Yi
机构信息
Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China.
出版信息
Org Lett. 2020 Jul 17;22(14):5390-5395. doi: 10.1021/acs.orglett.0c01715. Epub 2020 Jul 6.
A mild and efficient Rh(III)-catalyzed aliphatic C-H acetoxylation directed by quinolines has been developed with widespread functional groups, including various halogens, which usually can provide precursors for further organic synthesis but easily results in selectivity issues in the Pd- and Ni-catalyzed reaction. Interestingly, AcO plays an essential role in promoting the transformation.
已开发出一种温和且高效的铑（III）催化的、由喹啉导向的脂肪族C-H乙酰氧基化反应，该反应适用于广泛的官能团，包括各种卤素，这些官能团通常可为进一步的有机合成提供前体，但在钯和镍催化的反应中容易导致选择性问题。有趣的是，乙酰氧基在促进转化过程中起着至关重要的作用。
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