人表皮中的细胞质抗原和组织相容性抗原（HL-A抗原）

Cytoplasmic and HL-A antigens in the human epidermis.

作者信息

Saurat J H, Gluckman E, Didierjean L, Andersen E, Sockeel F, Puissant A

出版信息

Br J Dermatol. 1977 Jun;96(6):603-8. doi: 10.1111/j.1365-2133.1977.tb05203.x.

DOI:10.1111/j.1365-2133.1977.tb05203.x

Abstract

HL-A antisera were found to react, in indirect immunofluorescence on human skin, with the cytoplasm of the upper cell layers of the epidermis. It has been established that this staining was not due to an HL-A-antigen-antibody reaction but rather to a contamination of HL-A antisera with non-HL-A epidermal cytoplasmic antibodies. These findings ruled out a previous hypothesis that HL-A antigens were expressed in the cytoplasm of the upper epidermal cell layers. The localization of HL-A antigens in the human epidermis has not been demonstrated by use of indirect immunofluorescence.

摘要

发现HL - A抗血清在人皮肤的间接免疫荧光试验中，与表皮上层细胞的细胞质发生反应。已经确定这种染色不是由于HL - A抗原 - 抗体反应，而是由于HL - A抗血清被非HL - A表皮细胞质抗体污染所致。这些发现排除了先前关于HL - A抗原在表皮上层细胞质中表达的假设。使用间接免疫荧光法尚未证实HL - A抗原在人表皮中的定位。