Katayama K, Sakuma Y, Katayama S
Inflammation and Allergy Research Unit, Eisai Research Lab., Ibaraki, Japan.
Agents Actions Suppl. 1988;23:129-33. doi: 10.1007/978-3-0348-9156-1_9.
Anaphylactic bronchoconstriction in passively sensitized guinea-pigs was induced by intravenous injection of antigen (ovalbumin). Five min after injection of the antigen, when the increase in airways resistance to overflow (bronchospasm) was maximum, the plasma levels of leukotrienes LTC4 and LTD4 had increased from undetectable levels of 0.280 and 1.423 ng/ml, respectively. Administration of 5-lipoxygenase inhibitors clearly suppressed the increase in the leukotriene levels concomitant with the suppression of bronchospasm.
通过静脉注射抗原（卵清蛋白）在被动致敏的豚鼠中诱导过敏性支气管收缩。注射抗原5分钟后，当气道对溢流的阻力增加（支气管痉挛）达到最大时，白三烯LTC4和LTD4的血浆水平分别从未检测到的0.280和1.423 ng/ml增加。给予5-脂氧合酶抑制剂明显抑制了白三烯水平的增加，同时抑制了支气管痉挛。
