Small I F, Heimburger R F, Small J G, Milstein V, Moore D F
Biol Psychiatry. 1977 Jun;12(3):401-11.
Stereotaxic amygdalotomy for the control of unmanageable behavior and/or intractable seizures is a controversial treatment approach with unknown risk-to-benefit ratios. Information about this subject was obtained from a retrospective follow-up study of 58 patients who received this form of treatment 1 to 11 years earlier (average 6 years). Assessments of the patients were made by invesgators external to the surgical treatment system, using structured psychiatric interviews, neuropsychological tests, and EEGs. In addition, global assessments were made, comparing pre- versus postoperative status. The objective data revealed no indication of worsening or damage with similar pre- and postoperative test scores and EEG features. Computer-scored interviews revealed considerable psychopathology in the ambulatory patients. Overall judgments of behavior, seizures, and functional levels indicated that more than a third of the group was probably improved, although the relationship of outcome to the surgery was indeterminate.
立体定向杏仁核切开术用于控制难以管理的行为和/或难治性癫痫发作，是一种存在争议的治疗方法，其风险效益比尚不清楚。关于这一主题的信息来自一项对58例患者的回顾性随访研究，这些患者在1至11年前（平均6年）接受了这种治疗形式。由手术治疗系统以外的研究人员通过结构化精神科访谈、神经心理学测试和脑电图对患者进行评估。此外，还进行了整体评估，比较术前和术后的状况。客观数据显示，术前和术后测试分数及脑电图特征相似，没有恶化或损伤的迹象。计算机评分访谈显示，门诊患者存在相当程度的精神病理学问题。对行为、癫痫发作和功能水平的总体判断表明，尽管手术与结果的关系尚不确定，但该组中超过三分之一的患者可能有所改善。
