老年患者的组织细胞增多症X。补骨脂素光化学疗法后的超微结构和免疫细胞化学

Histiocytosis X in an elderly patient. Ultrastructure and immunocytochemistry after PUVA photochemotherapy.

作者信息

Neumann C, Kolde G, Bonsmann G

机构信息

Hautklinik Linden der Medizinischen Hochschule Hannover, West Germany.

出版信息

Br J Dermatol. 1988 Sep;119(3):385-91. doi: 10.1111/j.1365-2133.1988.tb03233.x.

DOI:10.1111/j.1365-2133.1988.tb03233.x

PMID:3263143

Abstract

The clinical features of a 76-year-old man with histiocytosis X of the Letterer-Siwe type, with extensive skin involvement, are described. The patient's lesions responded dramatically to PUVA-photochemotherapy. Light microscopic, immunocytochemical and immunoelectron microscopic findings, before and after PUVA, are reported. Birbeck granules in phagolysosomes of dermal macrophages indicated uptake of destroyed HX cells. Residual HX cells in the skin and HX cells in a recurring lesion expressed the same membrane antigens as in the primary lesions.

摘要

描述了一名76岁患有勒-雪氏病型组织细胞增多症X且皮肤广泛受累男性的临床特征。患者的皮损对补骨脂素紫外线A光化学疗法（PUVA）反应显著。报告了PUVA治疗前后的光镜、免疫细胞化学和免疫电镜检查结果。真皮巨噬细胞吞噬溶酶体中的伯贝克颗粒表明已摄取被破坏的组织细胞增多症X（HX）细胞。皮肤中的残留HX细胞和复发性皮损中的HX细胞表达与原发性皮损相同的膜抗原。