Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, National University, Sudan, Khartoum, Sudan.
BMC Res Notes. 2020 Jul 6;13(1):322. doi: 10.1186/s13104-020-05159-2.
Infection with the bacteria Helicobacter pylori has been classified as class one carcinogen associated with increasing susceptibility of gastritis and gastric carcinoma. This study is aiming at investigating the prevalence of H. pylori among colon polyps and colon cancer patients. A descriptive cross-sectional hospital-based study was conducted between February and June 2017. Sixty-nine formalin-fixed paraffin blocks collected from colon polyps and colon cancer patients to detect H. pylori using immunohistochemistry technique.
Of the 69 patients included in the study, 39 (56.5%) males and 30 (43.5%) were females, their age ranged from 21 to 80 years with a mean age of 47.1 ± 19.7. Of the 69 colon polyps and colon cancer patients, 44 (63.8%) were diagnosed as adenocarcinoma, 10 (14.5%) colitis, 15 (21.7%) juvenile polyposis syndrome. The results of immunohistochemistry technique showed the presence of 16 (23.2%) positive patients for H. pylori infection. Of these 16, 13 (81.3%) patients were diagnosed with adenocarcinoma and 3 (18.7%) patients were diagnosed with juvenile polyps. The results of H. pylori detection among the different colon polyps and colon cancer patients were showing a statistically significant association for H. pylori infection and adenocarcinoma, P value 0.028.
幽门螺杆菌（Helicobacter pylori）感染已被归类为一级致癌物，与胃炎和胃癌的易感性增加有关。本研究旨在调查结肠息肉和结肠癌患者中幽门螺杆菌的流行情况。本研究为 2017 年 2 月至 6 月期间进行的描述性横断面医院研究。使用免疫组织化学技术，从结肠息肉和结肠癌患者中检测了 69 例福尔马林固定石蜡包埋块中幽门螺杆菌的存在。
在纳入研究的 69 例患者中，39 例（56.5%）为男性，30 例（43.5%）为女性，年龄 21-80 岁，平均年龄 47.1±19.7 岁。在 69 例结肠息肉和结肠癌患者中，44 例（63.8%）诊断为腺癌，10 例（14.5%）为结肠炎，15 例（21.7%）为青少年息肉病综合征。免疫组织化学技术的结果显示，16 例（23.2%）患者幽门螺杆菌感染阳性。其中 13 例（81.3%）患者诊断为腺癌，3 例（18.7%）患者诊断为青少年息肉病。不同结肠息肉和结肠癌患者中幽门螺杆菌的检测结果显示，幽门螺杆菌感染与腺癌之间存在统计学显著关联，P 值为 0.028。
