干燥综合征与癌症。
Sjögren Syndrome and Cancer.
机构信息
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA.
The Metrohealth System, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
出版信息
Rheum Dis Clin North Am. 2020 Aug;46(3):513-532. doi: 10.1016/j.rdc.2020.05.004.
The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. This article discusses the accumulating data on various malignancies described in primary Sjögren syndrome, highlighting non-Hodgkin lymphoma and thyroid, multiple myeloma, and skin cancers. These reported associations may have clinical implications in daily practice and contribute to understanding of both autoimmunity and cancer.
许多研究已经证实了恶性肿瘤与风湿性疾病之间的关联。然而，对于风湿和肌肉骨骼疾病与恶性肿瘤相关的发病机制，我们的了解还很有限。有充分的证据表明干燥综合征与淋巴瘤之间存在关联，以及这些患者发生淋巴瘤的危险因素。本文讨论了原发性干燥综合征中描述的各种恶性肿瘤的累积数据，重点介绍了非霍奇金淋巴瘤和甲状腺癌、多发性骨髓瘤和皮肤癌。这些报道的关联可能对日常实践具有临床意义，并有助于理解自身免疫和癌症。
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