免疫检查点抑制是否会导致风湿性疾病？癌症相关耐受性丧失的机制和自身免疫病发病机制。
Immune Checkpoint Inhibition-Does It Cause Rheumatic Diseases? Mechanisms of Cancer-Associated Loss of Tolerance and Pathogenesis of Autoimmunity.
机构信息
Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55906, USA.
Division of Internal Medicine, Section of Rheumatology and Clinical Immunology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1465, Houston, TX, USA; Department of Rheumatology and Rehabilitation, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1465, Houston, TX, USA; Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.
出版信息
Rheum Dis Clin North Am. 2020 Aug;46(3):587-603. doi: 10.1016/j.rdc.2020.04.003. Epub 2020 Jun 7.
Mechanisms of immune checkpoints and their role in autoimmunity are discussed in the context of immune checkpoint inhibitor (ICI) therapy for cancer. The updated clinical spectrum of immune-related adverse events (irAEs), with an in-depth discussion of rheumatic irAEs, is presented. The relationship between ICI-induced loss of self-tolerance in cancer and the implications for understanding of irAEs, rheumatic irAEs in particular, is overviewed.
免疫检查点及其在自身免疫中的作用机制在癌症的免疫检查点抑制剂 (ICI) 治疗背景下进行了讨论。本文介绍了更新的免疫相关不良事件 (irAE) 的临床谱，并深入讨论了风湿性 irAE。本文还概述了 ICI 在癌症中诱导的自身耐受丧失与对 irAE（尤其是风湿性 irAE）的理解之间的关系。
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