Khonina N A, Shubinskiĭ G Z
Eksp Onkol. 1988;10(4):44-6.
The results of the study of natural cytotoxic activity of human peripheral blood lymphocytes are presented. Two types of natural killer cells isolated in discontinuous percoll density gradient have been shown to exist. Lymphocytes with low floating density lyse NK-sensitive target cells and leukemic B-lymphocytes, increase the lytic activity with respect to blasts of K-562 line under the effect of alpha-interferon. Lymphocytes isolated in percoll heavy fractions chiefly lyse leukemic B cells of patients by B-variant CLL and are not sensitive to the alpha-interferon effect.
本文展示了人类外周血淋巴细胞自然细胞毒性活性的研究结果。研究表明，通过不连续 Percoll 密度梯度分离出两种自然杀伤细胞。低漂浮密度的淋巴细胞可裂解 NK 敏感靶细胞和白血病 B 淋巴细胞，在α干扰素的作用下，对 K-562 细胞系的原始细胞的裂解活性增强。在 Percoll 重组分中分离出的淋巴细胞主要裂解 B 型慢性淋巴细胞白血病患者的白血病 B 细胞，且对α干扰素的作用不敏感。
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