Department of Neurosurgery, Mayo Clinic, 200 First St. SW, Gonda 8-214, Rochester, MN, 55905, USA.
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Acta Neurochir (Wien). 2020 Dec;162(12):3179-3187. doi: 10.1007/s00701-020-04466-8. Epub 2020 Jul 6.
Perineural spread (PNS) is an emerging mechanism for progressive, non-traumatic brachial plexopathy. We aim to summarize the pathologies (tumor and infection) shown to have spread along or to the brachial plexus, and identify the proposed mechanisms of perineural spread.
A focused review of the literature was performed pertaining to pathologies with identified perineural spread to the brachial plexus.
We summarized pathologies currently reported to have PNS in the brachial plexus and offer a structure for understanding and describing these pathologies with respect to their interaction with the peripheral nervous system.
Perineural spread is an underrepresented entity in the literature, especially regarding the brachial plexus. It can occur via a primary or secondary mechanism based on the anatomy, and understanding this mechanism helps to support biopsies of sacrificial nerve contributions, leading to more effective and timely treatment plans for patients.
神经周围扩散（PNS）是进行性非创伤性臂丛神经病的一种新兴机制。我们旨在总结显示沿臂丛或向臂丛扩散的病理学（肿瘤和感染），并确定神经周围扩散的拟议机制。
对文献进行了有针对性的回顾，涉及已确定有神经周围扩散到臂丛的病理学。
我们总结了目前报道的在臂丛中有 PNS 的病理学，并提供了一种理解和描述这些病理学的结构，以了解它们与周围神经系统的相互作用。
神经周围扩散在文献中是一个代表性不足的实体，尤其是在臂丛方面。它可以通过原发性或继发性机制发生，这取决于解剖结构，了解这种机制有助于支持牺牲性神经贡献的活检，从而为患者制定更有效和及时的治疗计划。
