Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro di Portillo 21, 00128, Rome, Italy.
Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, MO, USA.
Endocrine. 2020 Aug;69(2):237-240. doi: 10.1007/s12020-020-02407-0. Epub 2020 Jul 6.
Coronavirus 2019 disease (COVID-19) mostly adversely affects the elderly, a population at higher risk for low serum 25-hydroxyvitamin D (25(OH)D) levels. In this viewpoint, we highlight the well-known musculoskeletal properties of vitamin D, which are particularly relevant in the context of COVID-19, suggesting further potential benefits through extra-skeletal effects. Maintaining optimal 25(OH)D is crucial to prevent falls, frailty and fractures in elderly patients, with low activity levels due to lockdown, or who are relatively immobilized during hospitalization and after discharge for prolonged periods of time. Hypovitaminosis D is also associated with susceptibility to respiratory infections, admissions to the intensive care unit, and mortality. We underscore the importance of achieving desirable serum 25(OH)D in COVID-19 elderly patients, to ensure beneficial musculoskeletal effects and possibly respiratory effects of vitamin D, in the context of COVID-19.
2019 年冠状病毒病（COVID-19）主要对老年人产生不利影响，老年人血清 25-羟维生素 D（25（OH）D）水平较低，属于高危人群。在本观点中，我们重点介绍了维生素 D 的众所周知的肌肉骨骼特性，这在 COVID-19 背景下尤为重要，提示通过骨骼外作用可能具有进一步的潜在益处。维持最佳 25（OH）D 水平对于预防老年患者因封锁导致活动水平降低或因住院和出院后长时间相对固定而导致的跌倒、虚弱和骨折至关重要。维生素 D 缺乏症还与呼吸道感染、入住重症监护病房和死亡率有关。我们强调 COVID-19 老年患者实现理想血清 25（OH）D 的重要性，以确保维生素 D 产生有益的肌肉骨骼和可能的呼吸道作用。
