De Gramont A, Krulik M, Cady J, Lagadec B, Maisani J E, Loiseau J P, Grange J D, Gonzalez-Canali G, Demuynck B, Louvet C
Hôpital Saint-Antoine, Paris, France.
Eur J Cancer Clin Oncol. 1988 Sep;24(9):1499-503. doi: 10.1016/0277-5379(88)90341-0.
An enhanced antineoplastic effect of 5-fluorouracil in patients with advanced colorectal cancer has been produced either by combination with folinic acid or administration by continuous infusion. Thirty-seven patients with advanced measurable colorectal cancer received high-dose folinic acid (LV 200 mg/m2) followed by 5-fluorouracil i.v. bolus (300 mg/m2) and continuous infusion (300 mg/m2) on days 1 and 2 then 14 and 15 every 4 weeks. In the absence of toxicity, 5-FU was increased to 400 mg/m2 i.v. bolus and continuous infusion at course 2 and to 500 mg/m2 at course 3 and from course 4 maintained at 500 mg/m2. Responses were: complete responses: 1 (2.7%), partial responses: 19 (51.4%), no change: 8 (21.6%) and progressive disease: 9 (24.3%). CEA decrease was correlated with response. Median duration of response was 11 months. Median survival was 18 months, 21% of the patients were alive at 2 years. Toxicity was low, with diarrhea in 17% and nausea in 11.5% of the patients. LV-5-FU bolus and continuous infusion is safe and has definite activity in metastatic colorectal cancer.
5-氟尿嘧啶与亚叶酸联合使用或持续输注给药，均可增强晚期结直肠癌患者的抗肿瘤作用。37例晚期可测量的结直肠癌患者接受高剂量亚叶酸（LV 200 mg/m²），随后在第1天和第2天以及每4周后的第14天和第15天静脉推注5-氟尿嘧啶（300 mg/m²）并持续输注（300 mg/m²）。在无毒性的情况下，5-氟尿嘧啶在第2疗程时静脉推注和持续输注剂量增加至400 mg/m²，第3疗程时增加至500 mg/m²，从第4疗程起维持在500 mg/m²。疗效为：完全缓解1例（2.7%），部分缓解19例（51.4%），病情稳定8例（21.6%），疾病进展9例（24.3%）。癌胚抗原下降与疗效相关。中位缓解持续时间为11个月。中位生存期为18个月，21%的患者在2年时仍存活。毒性较低，17%的患者出现腹泻，11.5%的患者出现恶心。LV-5-FU静脉推注和持续输注在转移性结直肠癌中安全且有确切疗效。
