Oxford School of Nursing and Midwifery, Oxford Brookes University, Oxford, OX3 0FL, UK.
Faculty of Health Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
Support Care Cancer. 2021 Mar;29(3):1317-1325. doi: 10.1007/s00520-020-05594-8. Epub 2020 Jul 6.
Due to recent treatment advances, men are increasingly living longer with advanced prostate cancer (PCa). This study sought to understand men's experiences of living with and adjusting to advanced hormone-responsive PCa and how this influenced their quality of life (QoL), in order to highlight how support could be optimized.
Participants were recruited through a UK wide survey-the 'Life After Prostate Cancer Diagnosis' study. In-depth telephone interviews were conducted with 24 men (aged 46-77 years) with advanced (stage IV) hormone-responsive PCa diagnosed 18-42 months previously. Thematic analysis was undertaken using a framework approach.
Most participants perceived their QoL to be relatively good, which was influenced by the following factors (enablers to 'living well' with PCa): a sense of connectedness to others, engagement in meaningful activities, resources (social, cognitive, financial), ability to manage uncertainty, utilization of adjustment strategies and support, communication and information from health professionals. Barriers to 'living well' with PCa were often the converse of these factors. These also included more troublesome PCa-related symptoms and stronger perceptions of loss and restriction.
In our study, men living with advanced hormone-responsive PCa often reported a good QoL. Exploring the influences on QoL in men with advanced PCa indicates how future interventions might improve the QoL of men who are struggling. Further research is required to develop and test interventions that enhance QoL for these men.
由于最近的治疗进展，越来越多的男性患有晚期前列腺癌（PCa）并能存活更长时间。本研究旨在了解男性在患有和适应晚期激素反应性 PCa 方面的经历，以及这些经历如何影响他们的生活质量（QoL），以强调如何优化支持。
通过一项名为“前列腺癌诊断后生活”的英国全国性调查来招募参与者。对 24 名患有晚期（IV 期）激素反应性 PCa 的男性（年龄 46-77 岁）进行了深入的电话访谈，这些男性的诊断时间为 18-42 个月前。采用框架方法进行主题分析。
大多数参与者认为他们的 QoL 相对较好，这受到以下因素的影响（使 PCa“生活良好”的因素）：与他人的联系感、参与有意义的活动、资源（社会、认知、财务）、管理不确定性的能力、调整策略和支持的利用、来自卫生专业人员的沟通和信息。“与 PCa 生活良好”的障碍通常与这些因素相反。这些还包括更麻烦的 PCa 相关症状和更强的损失和限制感。
在我们的研究中，患有晚期激素反应性 PCa 的男性经常报告生活质量良好。探讨晚期 PCa 男性的 QoL 影响因素表明，未来的干预措施如何能够提高正在挣扎的男性的 QoL。需要进一步研究来开发和测试提高这些男性生活质量的干预措施。
