Charalampos Fragkoulis, Ioannis Glykas, Athanasios Pappas, Georgios Papadopoulos, Georgios Stathouros, Vasiliki Leontara, Athanasios Dellis, Akrivi Kostopoulou, Konstantinos Ntoumas
Urology Department. General Hospital of Athens "G.N.A. G. Gennimatas". Athens. Greece.
Urology Department. Athens Medical Group. Athens. Greece.
Arch Esp Urol. 2020 Jul;73(6):564-567.
Bladder Cancer (BC) is11th most common malignancy. In terms of pathology, the vast majority of patients suffer from transitional cell carcinoma. Apart from this common type of BC, there are many morphological subtypes with different oncological characteristics. Plasmacytoid BC is a well-recognized subtype of BC with great diagnostic importance as it usually presents in locally advanced or even metastatic stage.
The objective of this study was to evaluate our experience in diagnosing and treating patients with this rare BC subtype.
A retrospective analysis of 5 patients diagnosed with plasmacytoid BC in our department during they ears 2014-2016 was performed. Transurethral resection of the tumors was performed in all patients and pathology diagnosis of plasmacytoid variant was based on several morphologic and immunohistochemical parameters. Staging included abdominal and thoracic CT.
3 of 5 patients were diagnosed with metastatic disease. These patients were referred to the oncology department. 2 patients presented with non-metastatic BC after initial staging and thus a radical cystectomy was performed. Follow up of all patients was carried out and their survival was recorded.
We concluded that despite the fact that the plasmacytoid variant of BC is rare, it is important to take into account the pathologic and clinical features of this tumor in order to manage the optimal treatment of this poor prognosis cancer.
膀胱癌（BC）是第11大常见恶性肿瘤。在病理学方面，绝大多数患者患有移行细胞癌。除了这种常见类型的膀胱癌外，还有许多具有不同肿瘤学特征的形态学亚型。浆细胞样膀胱癌是一种公认的膀胱癌亚型，具有重要的诊断意义，因为它通常在局部晚期甚至转移阶段出现。
本研究的目的是评估我们在诊断和治疗这种罕见的膀胱癌亚型患者方面的经验。
对2014年至2016年期间在我科诊断为浆细胞样膀胱癌的5例患者进行回顾性分析。所有患者均行经尿道肿瘤切除术，浆细胞样变异型的病理诊断基于多个形态学和免疫组化参数。分期包括腹部和胸部CT。
5例患者中有3例被诊断为转移性疾病。这些患者被转诊至肿瘤科。2例患者在初始分期后表现为非转移性膀胱癌，因此进行了根治性膀胱切除术。对所有患者进行随访并记录其生存情况。
我们得出结论，尽管浆细胞样变异型膀胱癌很罕见，但考虑到该肿瘤的病理和临床特征对于优化这种预后不良癌症的治疗很重要。
