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左心室辅助装置相关性主动脉瓣反流患者经导管主动脉瓣植入术后急性重度右心衰竭的发生情况

Development of acute severe right heart failure after transcatheter aortic valve implantation in patient with left ventricle assist device-acquired aortic regurgitation.

作者信息

Bayram Zübeyde, Doğan Cem, Gürcü Emre, Kaymaz Cihangir, Özdemir Nihal

机构信息

Department of Cardiology, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey.

出版信息

Turk Kardiyol Dern Ars. 2020 Jul;48(5):545-551. doi: 10.5543/tkda.2020.39132.

DOI:10.5543/tkda.2020.39132
PMID:32633261
Abstract

A 58-year-old man with a left ventricular assist device (LVAD), which had been implanted 1 year earlier, presented with rest dyspnea. Moderate to severe aortic regurgitation (AR), pre-postcapillary pulmonary hypertension, modarete right ventricular (RV) failure, and low cardiac output were observed at presentation. Transcatheter aortic valve implantation (TAVI) was performed to treat the AR and a self-expandable aortic valve was implanted. Within minutes, hypotension, RV and inferior vena cava dilatation, and left atrial (LA) and left ventricular (LV) collapse occurred and persisted despite LVAD speed reduction. It was observed that severe RV failure had developed and venoarterial extracorporeal membrane oxygenation (VA-ECMO) was applied. Following VA-ECMO treatment, the RV dimensions decreased, and the LA and LV dimensions began to increase, as well as the LVAD flow. Weaning from VA-ECMO was unsuccessful and exitus occurred on the fifth day after TAVI secondary to RV failure. It was surmised that the decrease in blood circulation from the aorta to the LV after treatment of severe AR with TAVI caused an acute increase in the cardiac output and the RV preload. The acute increase in the RV preload led to acute severe right heart failure. It is necessary to prepare the RV to compete with an acute increase in preload before TAVI even when there is only modarete RV failure.

摘要

一名58岁男性,1年前植入了左心室辅助装置(LVAD),现因静息性呼吸困难就诊。就诊时发现有中度至重度主动脉瓣反流(AR)、毛细血管前后性肺动脉高压、中度右心室(RV)衰竭和低心输出量。为治疗AR进行了经导管主动脉瓣植入术(TAVI),并植入了一个自膨胀主动脉瓣。数分钟内,尽管降低了LVAD速度,但仍出现低血压、RV和下腔静脉扩张以及左心房(LA)和左心室(LV)塌陷,并持续存在。观察到发生了严重的RV衰竭,遂应用静脉-动脉体外膜肺氧合(VA-ECMO)。VA-ECMO治疗后,RV尺寸减小,LA和LV尺寸以及LVAD流量开始增加。VA-ECMO撤机未成功,TAVI术后第5天因RV衰竭死亡。据推测,TAVI治疗严重AR后从主动脉到LV的血液循环减少导致心输出量和RV前负荷急性增加。RV前负荷的急性增加导致急性严重右心衰竭。即使只有中度RV衰竭,在TAVI之前也有必要让RV做好应对前负荷急性增加的准备。

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引用本文的文献

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Transcatheter valvular therapies in patients with left ventricular assist devices.左心室辅助装置患者的经导管瓣膜治疗
Front Cardiovasc Med. 2023 Mar 13;10:1071805. doi: 10.3389/fcvm.2023.1071805. eCollection 2023.
2
A computational study of aortic insufficiency in patients supported with continuous flow left ventricular assist devices: Is it time for a paradigm shift in management?连续血流左心室辅助装置支持下患者主动脉瓣关闭不全的计算研究:管理模式是否该转变了?
Front Cardiovasc Med. 2022 Oct 20;9:933321. doi: 10.3389/fcvm.2022.933321. eCollection 2022.
3
Intraoperative ECMO assistance during TAVI for aortic insufficiency in an Asian patient with LVAD support.
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ESC Heart Fail. 2021 Aug;8(4):3418-3421. doi: 10.1002/ehf2.13426. Epub 2021 Jun 3.