Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
J Mater Chem B. 2020 Jul 28;8(28):6013-6016. doi: 10.1039/d0tb00173b. Epub 2020 Jul 7.
We present an approach for constructing a HS-specific nanoprobe by the entrapment of a small molecule probe within the hydrophobic interior of surface cross-linked micelles (SCMs), endowing the designed nanoprobes with good water solubility and biocompatibility. Importantly, the obtained nanoprobes displayed good responsiveness to HS in both ratiometric fluorescence and light-up NIR emission modes, thus enabling accurate identification of HS-rich colorectal cancer cells.
我们提出了一种通过将小分子探针包埋在表面交联胶束（SCM）的疏水性内部来构建 HS 特异性纳米探针的方法，使设计的纳米探针具有良好的水溶性和生物相容性。重要的是，所得到的纳米探针在比率荧光和点亮近红外发射模式下对 HS 均表现出良好的响应性，从而能够准确识别富含 HS 的结直肠癌细胞。
