Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Lab Med. 2021 Jan 4;52(1):16-23. doi: 10.1093/labmed/lmaa027.
The organization of the hematopoietic system is dependent on hematopoietic stem cells (HSCs) that are capable of self-renewal and multilineage differentiation to produce different blood cell lines. Autophagy has a central role in energy production and metabolism of the cells during starvation, cellular stress adaption, and removing mechanisms for aged or damaged organelles. The role and importance of autophagy pathways are becoming increasingly recognized in the literature because these pathways can be useful in organizing intracellular circulation, molecular complexes, and organelles to meet the needs of various hematopoietic cells. There is supporting evidence in the literature that autophagy plays an emerging role in the regulation of normal cells and that it also has important features in malignant hematopoiesis. Understanding the molecular details of the autophagy pathway can provide novel methods for more effective treatment of patients with leukemia. Overall, our review will emphasize the role of autophagy and its different aspects in hematological malignant neoplasms.
造血系统的组织依赖于造血干细胞（HSCs），这些细胞能够自我更新和多谱系分化，产生不同的血细胞系。自噬在饥饿、细胞应激适应和清除衰老或受损细胞器的机制中，对细胞的能量产生和代谢起着核心作用。自噬途径的作用和重要性在文献中越来越受到重视，因为这些途径可以用于组织细胞内循环、分子复合物和细胞器，以满足各种造血细胞的需求。文献中有证据表明，自噬在调节正常细胞方面发挥着新兴作用，在恶性造血方面也具有重要特征。了解自噬途径的分子细节可以为白血病患者的更有效治疗提供新方法。总的来说，我们的综述将强调自噬及其在血液恶性肿瘤中的不同方面的作用。
