Adak Tapas, Hu Chao, Rudolph Matthias, Li Jun, Hashmi A Stephen K
Organisch-Chemisches Institut, Im Neuenheimer Feld 270, Heidelberg University, Heidelberg 69120, Germany.
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Org Lett. 2020 Jul 17;22(14):5640-5644. doi: 10.1021/acs.orglett.0c01999. Epub 2020 Jul 7.
An eosin Y disodium salt-catalyzed photoredox C-H arylation of anthranils is reported. A variety of aryl diazonium tetrafluoroborates were used as aryl sources, providing the C3 cross-coupled products. The in situ generated reactive radicals were trapped by anthranils, providing an alternative method to transition-metal-catalyzed C-H arylations of anthranils. Gold-catalyzed downstream transformations demonstrate the synthetic potential of these valuable building blocks.
报道了一种曙红Y二钠盐催化的邻氨基苯甲腈的光氧化还原C-H芳基化反应。使用了多种芳基四氟硼酸重氮盐作为芳基源，得到了C3交叉偶联产物。原位生成的活性自由基被邻氨基苯甲腈捕获，为过渡金属催化的邻氨基苯甲腈的C-H芳基化提供了一种替代方法。金催化的后续转化展示了这些有价值的结构单元的合成潜力。
