Pacini Matteo, Maremmani Angelo G I, Maremmani Icro
G. De Lisio Institute of Behavioral Sciences, 56100 Pisa, Italy.
Department of Psychiatry, North-Western Tuscany Local Health Unit, Tuscany NHS, Versilia Zone, 55049 Viareggio, Italy.
J Clin Med. 2020 Jul 3;9(7):2098. doi: 10.3390/jcm9072098.
When psychiatric illness and substance use disorder coexist, the clinical approach to the patient is, unsurprisingly, awkward. This fact is due to a cultural context and, more directly, to the patient's psychiatric condition and addiction behaviors-a situation that does not favor a scientific approach. In dual disorder facilities, several types of professionals work together: counselors, social workers, psychologists, and psychiatrists. Treatment approaches vary from one service to another and even within the same service. It is crucial to provide dual disorder patients with multiple treatments, comprising hospitalization, rehabilitative and residential programs, case management, and counselling. Still, when treating dual disorder (DD) heroin use disorder (HUD) patients, it is advisable to follow a hierarchical algorithm. First, we must deal with addiction: by detoxification, whenever possible. This means starting most patients on anti-craving pharmacological maintenance, though aversion therapy may be appropriate for a few of them. Opiate antagonists may be used with heroin-addicted patients as long as those patients are only mildly ill. In contrast, agonist opioid medications, i.e., buprenorphine and methadone suit moderately and severely ill patients, respectively. Achieving control of mood instability or psychotic episodes is the next step, to be followed by a prevention strategy to counteract residual cravings and dominate mood disorders or psychotic episodes through long-term pharmacological maintenance that is focused on a double target.
当精神疾病与物质使用障碍并存时,对患者的临床治疗方法无疑会很棘手。这一情况归因于文化背景,更直接的是患者的精神状况和成瘾行为,这种情况不利于采用科学的治疗方法。在双相障碍治疗机构中,多种专业人员协同工作:咨询师、社会工作者、心理学家和精神科医生。不同服务之间甚至同一服务内部的治疗方法都各不相同。为双相障碍患者提供多种治疗至关重要,包括住院治疗、康复和住院项目、病例管理及咨询服务。不过,在治疗双相障碍合并海洛因使用障碍(DD - HUD)患者时,遵循分层算法是明智的。首先,我们必须处理成瘾问题:尽可能进行戒毒治疗。这意味着让大多数患者开始使用抗渴望药物维持治疗,尽管厌恶疗法可能适用于少数患者。只要海洛因成瘾患者病情较轻,就可以使用阿片类拮抗剂。相比之下,激动剂类阿片药物,即丁丙诺啡和美沙酮分别适用于病情中度和重度的患者。下一步是控制情绪不稳定或精神病发作,随后是通过针对双重目标的长期药物维持治疗来对抗残留渴望并控制情绪障碍或精神病发作的预防策略。