Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Division of Advanced Materials and Healthcare Technologies School of Pharmacy, Centre for Analytical Bioscience, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Int J Mol Sci. 2020 Jul 3;21(13):4753. doi: 10.3390/ijms21134753.
Women with polycystic ovary syndrome (PCOS) are more likely to develop endometrial cancer (EC). The molecular mechanisms which increase the risk of EC in PCOS are unclear. Derangements in lipid metabolism are associated with EC, but there have been no studies, investigating if this might increase the risk of EC in PCOS. This was a cross-sectional study of 102 women in three groups of 34 (PCOS, EC and controls) at Nottingham University Hospital, UK. All participants had clinical assessments, followed by obtaining plasma and endometrial tissue samples. Lipidomic analyses were performed using liquid chromatography (LC) coupled with high resolution mass spectrometry (HRMS) and the obtained lipid datasets were screened using standard software and databases. Using multivariate data analysis, there were no common markers found for EC and PCOS. However, on univariate analyses, both PCOS and EC endometrial tissue samples showed a significant decrease in monoacylglycerol 24:0 and capric acid compared to controls. Further studies are required to validate these findings and investigate the potential role of monoacylglycerol 24:0 and capric acid in the link between PCOS with EC.
多囊卵巢综合征（PCOS）女性更易发生子宫内膜癌（EC）。导致 PCOS 发生 EC 风险增加的分子机制尚不清楚。脂代谢紊乱与 EC 相关，但目前尚无研究探讨这是否会增加 PCOS 发生 EC 的风险。这是英国诺丁汉大学医院的一项横断面研究，纳入了三组各 34 名患者，共 102 名女性，分别为 PCOS 组、EC 组和对照组。所有参与者均进行临床评估，然后采集血浆和子宫内膜组织样本。采用液相色谱（LC）-高分辨率质谱（HRMS）联用技术进行脂质组学分析，并用标准软件和数据库筛选获得的脂质数据集。通过多变量数据分析，未发现 EC 和 PCOS 的共同标志物。然而，单变量分析显示，与对照组相比，PCOS 和 EC 子宫内膜组织样本中的 24:0 单酰基甘油和癸酸显著减少。需要进一步的研究来验证这些发现，并探讨 24:0 单酰基甘油和癸酸在 PCOS 与 EC 之间的联系中的潜在作用。
