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Recurrent and Drastic Increase in Dabigatran Levels May Be Induced by Therapeutic Plasma Exchange.治疗性血浆置换可能导致达比加群水平反复且急剧升高。
J Stroke. 2020 May;22(2):266-267. doi: 10.5853/jos.2019.03601. Epub 2020 May 31.
2
The effect of dabigatran on the activated partial thromboplastin time and thrombin time as determined by the Hemoclot thrombin inhibitor assay in patient plasma samples.达比加群对患者血浆样本中 Hemoclot 凝血酶抑制剂测定法检测的活化部分凝血活酶时间和凝血酶时间的影响。
Thromb Haemost. 2013 Aug;110(2):308-15. doi: 10.1160/TH13-04-0301. Epub 2013 Jun 20.
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Removal of dabigatran using sorbent hemadsorption.使用吸附剂血液吸附法清除达比加群。
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Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation.达比加群在减轻机械心脏瓣膜诱导的凝血酶生成方面不如华法林有效。
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Dabigatran plasma levels, aPTT and thromboelastography in patients with AF: implications for allowing early non-elective surgical procedures.房颤患者的达比加群血浆水平、活化部分凝血活酶时间及血栓弹力图：对允许早期非择期外科手术的意义
J Thromb Thrombolysis. 2017 Jul;44(1):9-13. doi: 10.1007/s11239-017-1503-3.
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The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy).达比加群血浆浓度和患者特征对房颤患者缺血性卒中和大出血发生率的影响：RE-LY 试验（随机评估长期抗凝治疗）。
J Am Coll Cardiol. 2014 Feb 4;63(4):321-8. doi: 10.1016/j.jacc.2013.07.104. Epub 2013 Sep 27.
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Interpretation of point-of-care INR results in patients treated with dabigatran.即时 INR 结果解读在接受达比加群治疗的患者中的应用。
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Performance of various laboratory assays in the measurement of dabigatran in patients receiving therapeutic doses: a prospective study based on peak and trough plasma levels.各种实验室检测方法在治疗剂量下检测达比加群患者中的表现：一项基于峰浓度和谷浓度的前瞻性研究。
Am J Clin Pathol. 2014 Feb;141(2):262-7. doi: 10.1309/AJCPRNUMI4PVSJ7Q.
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Determination of dabigatran in plasma, serum, and urine samples: comparison of six methods.血浆、血清和尿液样本中达比加群的测定：六种方法的比较
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10
Dabigatran reduces thrombin-induced platelet aggregation and activation in a dose-dependent manner.达比加群以剂量依赖的方式降低凝血酶诱导的血小板聚集和活化。
J Thromb Thrombolysis. 2017 Aug;44(2):216-222. doi: 10.1007/s11239-017-1512-2.

本文引用的文献

1
Direct thrombin inhibitors: a case indicating benefit from 'plasmapheresis' in toxicity: a call for establishing "guidelines" in overdose and to find an "antidote"!直接凝血酶抑制剂：一例表明在毒性中“血浆置换”有益的案例：呼吁制定过量使用的“指南”并寻找“解毒剂”！
Am J Ther. 2012 Nov;19(6):e182-5. doi: 10.1097/MJT.0b013e3182459a79.

Recurrent and Drastic Increase in Dabigatran Levels May Be Induced by Therapeutic Plasma Exchange.

作者信息

Pflug Marc A, Schellinger Peter D

机构信息

Department of Neurology and Neurogeriatrics, Johannes Wesling Medical Center Minden, University Clinic RUB, Minden, Germany.

出版信息

J Stroke. 2020 May;22(2):266-267. doi: 10.5853/jos.2019.03601. Epub 2020 May 31.

DOI:10.5853/jos.2019.03601
PMID:32635692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7341013/
Abstract
摘要