促肾上腺皮质激素释放激素刺激对抑郁症患者的精神药物作用。
Psychotropic effects of corticotropin-releasing hormone stimulation in depressive patients.
作者信息
Laux G, Lesch K P, Schwab M
机构信息
Department of Psychiatry, University of Würzburg, FRG.
出版信息
Neuropsychobiology. 1988;19(1):40-4. doi: 10.1159/000118431.
Synthetic human corticotropin-releasing hormone (hCRH) was administered as an intravenous bolus (100 micrograms) to 13 patients suffering from endogenous depression and to 12 healthy volunteers. Compared with controls, depressed patients showed a significant amelioration of mood and well-being 2 h after hCRH administration in the rating scales applied ('Befindlichkeits-Skala', 'Eigenschaftswörterliste', 'Kurzskala Stimmung-Aktivierung', Self-Rating Depression Scale, Hamilton Rating Scale for Depression). Based on our preliminary data, a psychotropic effect and at least a mediating function of hCRH regarding pathophysiology and etiopathogenesis of endogenous depressions must be assumed.
将合成的人促肾上腺皮质激素释放激素（hCRH）以静脉推注（100微克）的方式给予13名内源性抑郁症患者和12名健康志愿者。与对照组相比，在应用的评分量表（“状态量表”、“特质词表”、“情绪-激活简表”、自评抑郁量表、汉密尔顿抑郁评定量表）中，抑郁症患者在给予hCRH后2小时情绪和幸福感有显著改善。基于我们的初步数据，必须假定hCRH对内源性抑郁症的病理生理学和病因学具有精神otropic作用和至少一种中介功能。
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