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Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system.全基因组测序揭示了胰岛素瘤和无功能性胰腺神经内分泌肿瘤的不同遗传基础：导致了一个新的分类系统。
Gut. 2020 May;69(5):877-887. doi: 10.1136/gutjnl-2018-317233. Epub 2019 Aug 28.
2
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.单细胞 RNA 测序凸显胰腺导管腺癌肿瘤内异质性和恶性演进。
Cell Res. 2019 Sep;29(9):725-738. doi: 10.1038/s41422-019-0195-y. Epub 2019 Jul 4.
3
Whole-genome landscape of pancreatic neuroendocrine tumours.胰腺神经内分泌肿瘤的全基因组图谱。
Nature. 2017 Mar 2;543(7643):65-71. doi: 10.1038/nature21063. Epub 2017 Feb 15.
4
Propensity score-matched analysis of robotic versus open surgical enucleation for small pancreatic neuroendocrine tumours.机器人与开放式手术摘除法治疗小型胰腺神经内分泌肿瘤的倾向评分匹配分析。
Br J Surg. 2016 Sep;103(10):1358-64. doi: 10.1002/bjs.10220. Epub 2016 Aug 2.
5
Plasma miRNAs Effectively Distinguish Patients With Pancreatic Cancer From Controls: A Multicenter Study.血浆微小RNA可有效区分胰腺癌患者与对照者：一项多中心研究
Ann Surg. 2016 Jun;263(6):1173-9. doi: 10.1097/SLA.0000000000001345.
6
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.癌症治疗中的免疫检查点靶向治疗：迈向具有治愈潜力的联合策略。
Cell. 2015 Apr 9;161(2):205-14. doi: 10.1016/j.cell.2015.03.030.
7
Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors.DAXX 和 ATRX 的缺失与染色体不稳定性和胰腺神经内分泌肿瘤患者的生存降低有关。
Gastroenterology. 2014 Feb;146(2):453-60.e5. doi: 10.1053/j.gastro.2013.10.020. Epub 2013 Oct 19.
8
Robotic versus open pancreatectomy: a systematic review and meta-analysis.机器人手术与开腹胰切除术：系统评价和荟萃分析。
Ann Surg Oncol. 2013 Jun;20(6):1774-80. doi: 10.1245/s10434-012-2823-3. Epub 2013 Mar 17.
9
Surgical management of patients with insulinomas: Result of 292 cases in a single institution.胰岛素瘤患者的外科治疗：单中心 292 例结果。
J Surg Oncol. 2011 Feb;103(2):169-74. doi: 10.1002/jso.21773. Epub 2010 Dec 22.
10
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.DAXX/ATRX、MEN1 和 mTOR 通路基因在胰腺神经内分泌肿瘤中经常发生改变。
Science. 2011 Mar 4;331(6021):1199-203. doi: 10.1126/science.1200609. Epub 2011 Jan 20.

Genomic and single cell sequencing facilitate the dissection of heterogeneity of pancreatic tumors.

作者信息

Edil Barish H, Luo Wenyi, Li Min

机构信息

Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

出版信息

BMC Med. 2020 Jul 8;18(1):177. doi: 10.1186/s12916-020-01637-3.

DOI:10.1186/s12916-020-01637-3
PMID:32635908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7341579/
Abstract
摘要