Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele - Milan, Italy.
Humanitas Clinical and Research Center - IRCCS, Via Manzoni 56, 20089, Rozzano (Mi), Italy.
J Med Case Rep. 2020 Jul 8;14(1):92. doi: 10.1186/s13256-020-02430-9.
The finding of hematological malignancies within bone marrow in heterotopic ossification has been reported only a handful of times previously in the literature. We described a case of true trilineage hematopoiesis in an excised area of heterotopic ossification from an enucleated blind painful eye.
A 70-year-old Caucasian man, positive for asymptomatic lymphoplasmacytic lymphoma, presented with a blind painful right eye in our ophthalmology department to evaluate enucleation bulbi. After enucleation, a histopathologic examination revealed the presence of intertrabecular infiltration in the metaplastic bone marrow of non-Hodgkin B lymphoma, with small lymphocytes, with similar characteristics to the already known disease.
This uncommon case reveals the possibility of the localization of malignant cells within bone metaplasia of intraocular ossification in an enucleated blind painful eye. From a practical point of view, a careful systematic histopathological examination of all resected tissues in patients with a history of malignant neoplastic pathology is necessary to confirm the diagnosis and exclude occult malignancies.
在异位骨化的骨髓中发现血液系统恶性肿瘤，此前在文献中仅报道过少数几次。我们描述了一例在已摘除的盲眼疼痛眼的异位骨化切除区域中真正的三系造血的病例。
一名 70 岁的白人男性，患有无症状的淋巴浆细胞淋巴瘤，因右眼盲且疼痛到我们的眼科就诊，以评估眼球摘除术。眼球摘除后，组织病理学检查显示非霍奇金 B 淋巴瘤的骨髓化生中有小梁间浸润，存在小淋巴细胞，与已知的疾病具有相似特征。
这个罕见的病例揭示了恶性细胞在已摘除的盲眼疼痛眼的眼内骨化的骨化生中定位的可能性。从实际的角度来看，对于有恶性肿瘤病史的患者，有必要对所有切除的组织进行仔细的系统组织病理学检查，以确认诊断并排除隐匿性恶性肿瘤。
