Department of Internal Medicine, Medical Faculty, Ondokuz Mayıs University, Samsun, Turkey.
Department of Rheumatology, Medical Faculty, Ondokuz Mayıs University, Samsun, Turkey.
Am J Med Sci. 2020 Nov;360(5):560-565. doi: 10.1016/j.amjms.2020.05.029. Epub 2020 May 29.
Idiopathic granulomatous mastitis is a rare inflammatory disease of the breast, for which there is a lack of consensus on the treatment protocol; it requires long-term follow-up and is associated with a high rate of relapse after surgical treatment. In this study, we report on the largest single-center cohort of idiopathic granulomatous mastitis treated with steroids + methotrexate.
We retrospectively examined the data of 33 patients histopathologically diagnosed with idiopathic granulomatous mastitis who were evaluated by our Rheumatology or General Surgery Clinics between 2013 and 2016.
Of the 33 female patients (age: 38.64 ± 6.9 years), 24 were admitted with an initial diagnosis of idiopathic granulomatous mastitis, whereas 9 were admitted after surgical treatment. Remission was achieved in 87.9% of patients with steroid + methotrexate treatment, and there were no relapses during the 24-months follow-up period.
Steroid + methotrexate treatment is an effective and reliable method for ensuring long-term remission in patients with idiopathic granulomatous mastitis diagnosis.
特发性肉芽肿性乳腺炎是一种罕见的乳腺炎症性疾病，其治疗方案尚未达成共识；需要长期随访，且手术后复发率较高。本研究报告了在我们的风湿病或普外科诊所就诊的经组织病理学诊断为特发性肉芽肿性乳腺炎的患者中，使用类固醇+甲氨蝶呤治疗的最大单中心队列。
我们回顾性分析了 2013 年至 2016 年间在我们的风湿病或普外科诊所就诊的 33 名经组织病理学诊断为特发性肉芽肿性乳腺炎的女性患者的数据。
33 名女性患者（年龄：38.64±6.9 岁）中，24 名最初被诊断为特发性肉芽肿性乳腺炎，9 名在手术后入院。87.9%的患者接受类固醇+甲氨蝶呤治疗后达到缓解，24 个月随访期间无复发。
类固醇+甲氨蝶呤治疗是确保特发性肉芽肿性乳腺炎患者长期缓解的有效且可靠的方法。
