XEN凝胶支架：关于其作为难治性青光眼治疗选择应用的综合综述
XEN Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma.
作者信息
Fea Antonio M, Durr Georges M, Marolo Paola, Malinverni Lorenza, Economou Mario A, Ahmed Ike
机构信息
Struttura Complessa Oculistica, Città Della Salute e Della Scienza di Torino, Dipartimento di Scienze Chirurgiche - Università Degli Studi di Torino, Torino, Italy.
Department of Ophthalmology, Université de Montréal, Montréal, Québec, Canada.
出版信息
Clin Ophthalmol. 2020 Jun 30;14:1805-1832. doi: 10.2147/OPTH.S178348. eCollection 2020.
Abstract
The XEN Gel Microstent is a subconjunctival microinvasive glaucoma surgical device developed with the aim of improving the predictability and safety profile of bleb-forming glaucoma surgical procedures. The stent is a hydrophilic tube composed of a porcine gel cross-linked with glutaraldehyde with good stability and biocompatibility with minimal tissue reaction. This device has demonstrated promising outcomes with fewer risks compared to traditional surgeries. The aim of the review is to present early studies on different designs of the XEN Gel Stent, to summarize different surgical techniques of implantation and to analyze more comprehensively the results, complications and rates of needling of the commercially available device (Xen 45). The review will address separately special cases (PXG, UVG, ICE, congenital glaucoma) and describe small series and case reports.
摘要
XEN凝胶微支架是一种结膜下微创青光眼手术装置，其研发目的是提高形成滤过泡的青光眼手术的可预测性和安全性。该支架是一种亲水管，由与戊二醛交联的猪凝胶组成，具有良好的稳定性和生物相容性，组织反应极小。与传统手术相比，该装置已显示出有前景的结果且风险更低。本综述的目的是介绍关于XEN凝胶支架不同设计的早期研究，总结不同的植入手术技术，并更全面地分析市售装置（Xen 45）的结果、并发症和针刺率。本综述将分别探讨特殊病例（色素性青光眼、无色素性青光眼、ICE综合征、先天性青光眼），并描述小样本系列研究和病例报告。
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本文引用的文献
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European study of the efficacy of a cross-linked gel stent for the treatment of glaucoma.欧洲交联凝胶支架治疗青光眼疗效的研究。
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XEN Gel Stent in Pediatric Glaucoma.XEN 凝胶支架在儿童青光眼中的应用。
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The treatment of a hypertrophic bleb after XEN gel implantation with the "Drainage Channel with sutures" method: a case report.XEN 凝胶植入术后应用“带缝线引流通道”方法治疗肥厚性滤过泡：一例报告。
BMC Ophthalmol. 2019 Dec 3;19(1):245. doi: 10.1186/s12886-019-1249-0.
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Efficacy of Needling Revision After XEN Gel Stent Implantation: A Prospective Study.XEN 凝胶支架植入后针刺修复的疗效：一项前瞻性研究。
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Urgent Management of Secondary Glaucoma in Uveitis Using the Xen-45 Gel Stent.Xen-45 凝胶支架在葡萄膜炎继发性青光眼的紧急处理中的应用
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