Gunji Venkateswarlu, Seru Ganapaty
A.M. Reddy Memorial College of Pharmacy, Department of Pharmacognosy and Phytochemistry, Andhra Pradesh, India.
GITAM Institute of Pharmacy, Department of Pharmacognosy and Phytochemistry, Andhra Pradesh, India.
Turk J Pharm Sci. 2020 Jun;17(3):329-336. doi: 10.4274/tjps.galenos.2018.60566. Epub 2020 Jun 22.
The analgesic and anti-inflammatory effects of methanolic extract of (MELR) were assessed at 200 and 400 mg/kg.
In carrageenan-mediated paw edema, the anti-inflammatory effect of MELR was investigated and analgesic activity was assessed by central and peripheral models.
MELR had strong analgesic and anti-inflammatory effects at different dosages (200 and 400 mg/kg). The study results confirmed the use of as both an analgesic and anti-inflammatory. The strong anti-inflammatory and analgesic effects can be caused by anabolic steroids, i.e. β-sitosterol and stigmasterol; and flavonoids, i.e. quercetin and glycosides, in the extraction of some kind of inflamed arbitrators.
Based on the study, we can conclude that repens had analgesic and anti-inflammatory activity. In addition to organic studies, however, additional phytochemicals are required to evaluate the extra energetic chemicals responsible for the antinociceptive and anti-inflammatory effects.
评估白车轴草甲醇提取物（MELR）在200和400毫克/千克剂量下的镇痛和抗炎作用。
在角叉菜胶介导的爪肿胀实验中，研究MELR的抗炎作用，并通过中枢和外周模型评估其镇痛活性。
MELR在不同剂量（200和400毫克/千克）下具有较强的镇痛和抗炎作用。研究结果证实白车轴草可作为一种镇痛和抗炎药物。其强大的抗炎和镇痛作用可能由合成代谢类固醇，即β-谷甾醇和豆甾醇；以及黄酮类化合物，即槲皮素及其糖苷，在某种炎症介质的提取物中引起。
基于该研究，我们可以得出结论，白车轴草具有镇痛和抗炎活性。然而，除了有机研究外，还需要额外的植物化学物质来评估负责抗伤害感受和抗炎作用的额外活性化学成分。
