Brett Elizabeth A, Sauter Matthias A, Machens Hans-Günther, Duscher Dominik
Department of Plastic and Hand Surgery, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany.
Cancer Metab. 2020 Jul 2;8:14. doi: 10.1186/s40170-020-00221-w. eCollection 2020.
In 2006, a new model of invasive breast tumor emerged and, since 2011, is gaining recognition and research momentum. "Tumor-associated collagen signatures" describe 3 distinct layers of collagen which radiate outward in shells from the main body of the tumor. The outermost layer (TACS3) features branches of collagen radiating away from the tumor, 90° perpendicular to the tumor surface. TACS3 increases tumor span and correlates directly with metastasis, though presently difficult to detect in breast tissue. TACS is an emerging model but has been validated by multiple labs in vitro and in vivo, specifically for breast cancer prognostics. Newly recognized and accepted tumor borders will impact both R0 resections and downstream surgical reconstruction. This review aims to comprehensively introduce and connect the ranging literature on linearized collagen of invasive tumor borders. Using PubMed keyword searches containing "aligned," "linear," "oriented," and "organized," we have gathered the studies on TACS, integrated the concept into the clinic, and projected future platforms.
2006年，一种新的浸润性乳腺肿瘤模型出现了，自2011年以来，它越来越受到认可并获得研究动力。“肿瘤相关胶原特征”描述了3层不同的胶原，它们从肿瘤主体呈壳状向外辐射。最外层（TACS3）的特征是胶原分支从肿瘤向外辐射，与肿瘤表面呈90°垂直。TACS3增加肿瘤跨度并与转移直接相关，尽管目前在乳腺组织中难以检测到。TACS是一个新兴模型，但已在多个实验室的体外和体内得到验证，特别是用于乳腺癌的预后评估。新认识和接受的肿瘤边界将影响R0切除和下游的手术重建。本综述旨在全面介绍和连接关于浸润性肿瘤边界线性化胶原的广泛文献。通过使用包含“排列的”“线性的”“定向的”和“有序的”等关键词在PubMed上进行搜索，我们收集了关于TACS的研究，将这一概念整合到临床中，并预测了未来的平台。
