Kubota Manabu, Moriguchi Sho, Takahata Keisuke, Nakajima Shinichiro, Horita Nobuyuki
Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Department of Psychiatry, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Data Brief. 2020 Jun 16;31:105862. doi: 10.1016/j.dib.2020.105862. eCollection 2020 Aug.
This article describes a dataset for a meta-analysis that aimed to investigate the effects of treatment on the neurometabolite status in patients with schizophrenia (DOI of original article: https://doi.org/10.1016/j.schres.2020.03.069[1]). The data search was performed with MEDLINE, Embase, and PsycINFO. The neurometabolites investigated include glutamate, glutamine, glutamate + glutamine, gamma-aminobutyric acid, -acetylaspartate, and myo-inositol, and the regions of interest (ROIs) include the frontal cortex, temporal cortex, parieto-occipital cortex, thalamus, basal ganglia, and hippocampus. The meta-analysis was conducted with a random-effects model, and the use of the standardized mean difference method between pre- and post-treatment of subjects for neurometabolites in each ROI of three patient groups or more. The dataset covers raw data of 39 patient groups (773 patients with schizophrenia at follow-up) with neurometabolite levels measured by magnetic resonance spectroscopy both before and after treatment. Furthermore, it contains details of clinical characteristics and treatment types for each group. Therefore, the data would be useful for a reinvestigation of treatment effects on the neurometabolite status from diverse points of view, as well as for the development of future treatment strategies for psychiatric diseases.
本文描述了一项荟萃分析的数据集，该分析旨在研究治疗对精神分裂症患者神经代谢物状态的影响（原始文章的DOI：https://doi.org/10.1016/j.schres.2020.03.069[1]）。数据检索通过MEDLINE、Embase和PsycINFO进行。所研究的神经代谢物包括谷氨酸、谷氨酰胺、谷氨酸+谷氨酰胺、γ-氨基丁酸、N-乙酰天门冬氨酸和肌醇，感兴趣的区域（ROI）包括额叶皮质、颞叶皮质、顶枕叶皮质、丘脑、基底神经节和海马体。荟萃分析采用随机效应模型，对三个或更多患者组每个ROI中神经代谢物的治疗前和治疗后受试者使用标准化平均差方法。该数据集涵盖了39个患者组（随访时773名精神分裂症患者）的原始数据，这些患者组在治疗前后均通过磁共振波谱测量了神经代谢物水平。此外，它还包含每组的临床特征和治疗类型的详细信息。因此，这些数据将有助于从不同角度重新研究治疗对神经代谢物状态的影响，以及用于精神疾病未来治疗策略的开发。
