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基于纤维素的用于具有抗菌和伤口愈合特性的治疗物质持续释放的超分子水凝胶的制备与评估数据。

Data of preparation and evaluation of supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties.

作者信息

Marican Adolfo, Forero-Doria Oscar, Polo Efrain, Gallego Jaime, Durán-Lara Esteban F

机构信息

Instituto de Química de Recursos Naturales, Universidad de Talca, Talca 3460000, Maule, Chile.

Bio & NanoMaterials Lab, Drug Delivery and Controlled Release, Universidad de Talca, Talca 3460000, Maule, Chile.

出版信息

Data Brief. 2020 Jun 21;31:105902. doi: 10.1016/j.dib.2020.105902. eCollection 2020 Aug.

Abstract

The data article refers to the paper "supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties"[1]. The dataset includes the synthesis and characterization of (E)-1,3-bis(4-(allyloxy)phenyl)prop‑2-en-1-one (3) (crosslinking agent). Moreover, the multiwall carbon nanotubes (MWCNTs) synthesis and functionalization (MWCNTs-COOH) are described. The formulation obtained by adding multiwalled carbon nanotubes-COOH with the crosslinked cellulose-chalcone hydrogel is abbreviated as MWCNTsCCH, and the same formulation loaded with therapeutic substances (TS) is named MWCNTsCCH-TS. The MWCNTsCCH database such as components and their amounts, swelling degree, thermogravimetric analysis, and cytotoxicity evaluation are depicted. Finally, to elucidate the mechanism of therapeutic substances release, the obtained averages of the release profiles were fitted through mathematical models.

摘要

数据文章引用了论文《基于纤维素的超分子水凝胶用于具有抗菌和伤口愈合特性的治疗物质的持续释放》[1]。该数据集包括(E)-1,3-双(4-(烯丙氧基)苯基)丙-2-烯-1-酮(3)(交联剂)的合成与表征。此外,还描述了多壁碳纳米管(MWCNTs)的合成与功能化(MWCNTs-COOH)。通过将多壁碳纳米管-COOH与交联的纤维素-查尔酮水凝胶添加而获得的制剂缩写为MWCNTsCCH,负载治疗物质(TS)的相同制剂命名为MWCNTsCCH-TS。描绘了MWCNTsCCH数据库,如成分及其含量、溶胀度、热重分析和细胞毒性评估。最后,为了阐明治疗物质的释放机制,通过数学模型对获得的释放曲线平均值进行拟合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15d/7330148/a013171f30de/gr1.jpg

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