Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Med Res Rev. 2021 Mar;41(2):754-769. doi: 10.1002/med.21704. Epub 2020 Jul 8.
Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of experimental brain ischemia. These changes significantly affect signaling and metabolic pathways, affecting various body systems and confirming the multiple target actions of peptides. The importance of noncoding RNAs in the regulation of these processes is shown, and we discuss the prospects of research for determining the main mechanisms of peptide regulation, which is necessary for the further development of drugs with targeted neuroprotective effects.
在这里，我们回顾了具有神经保护特性的肽对神经细胞基因转录影响的研究。该领域发表的少数几篇研究论文清楚地表明，在正常条件和实验性脑缺血条件下，肽可引起细胞转录组的大规模变化。这些变化显著影响信号和代谢途径，影响各种身体系统，并证实肽具有多种靶向作用。研究非编码 RNA 在这些过程中的调控作用具有重要意义，我们讨论了确定肽调控主要机制的研究前景，这对于进一步开发具有靶向神经保护作用的药物是必要的。
