下丘脑功能失调、通气不足和自主神经功能失调综合征所致快速起病肥胖儿童的慢波睡眠活动改变
Altered slow-wave sleep activity in children with rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation syndrome.
作者信息
Goldbart Aviv D, Arazi Ayelet, Golan-Tripto Inbal, Levinsky Yoel, Scheuerman Oded, Tarasiuk Ariel
机构信息
Department of Pediatrics B, Soroka University Medical Center, Beer-Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
J Clin Sleep Med. 2020 Oct 15;16(10):1731-1735. doi: 10.5664/jcsm.8678.
STUDY OBJECTIVES
Rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare condition. Little is known about sleep/wake and slow-wave activity in this condition, although the central hypothalamic dysfunction associated with autonomic dysregulation would make the occurrence of SWA deregulation most likely.
METHODS
Two children with clinical presentation of ROHHAD syndrome were evaluated, diagnosed, and treated. Their polysomnographic studies were compared with 4 matched children with obstructive sleep apnea and 6 controls.
RESULTS
Children that were clinically diagnosed with ROHHAD exhibited significantly weaker slow-wave activity power and shallower slow-wave activity slopes during the first 2 sleep cycles compared with children with obstructive sleep apnea or controls.
CONCLUSIONS
This study shows that children with ROHHAD have suppressed slow-wave activity, possibly because of hypothalamic dysregulation that may contribute to their rapid-onset obesity and excessive daytime sleepiness.
研究目的
伴有下丘脑功能失调、通气不足和自主神经功能失调的快速发作性肥胖症（ROHHAD）是一种罕见病症。尽管与自主神经功能失调相关的下丘脑中枢功能障碍很可能导致慢波活动失调，但关于这种病症中的睡眠/觉醒及慢波活动情况，人们所知甚少。
方法
对两名有ROHHAD综合征临床表现的儿童进行了评估、诊断和治疗。将他们的多导睡眠图研究结果与4名匹配的阻塞性睡眠呼吸暂停儿童及6名对照儿童进行了比较。
结果
与阻塞性睡眠呼吸暂停儿童或对照儿童相比，临床诊断为ROHHAD的儿童在前两个睡眠周期中慢波活动功率明显较弱，慢波活动斜率较浅。
结论
本研究表明，ROHHAD儿童存在慢波活动受抑制的情况，这可能是由于下丘脑功能失调所致，而下丘脑功能失调可能导致他们快速发作性肥胖和日间过度嗜睡。
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