Guo Jun-Cheng, Li Xiang, Guo Min, Gao Yun-Suo, Fu Lin-Qiu, Jiang Xiang-Ling, Fu Lin-Mei, Huang Tao
Affiliated Haikou Hospital, School of Medical, Central South University Xiangya, Haikou, Hainan Province, China.
The Third People's Hospital of Hubei Province, Wuhan, China.
Rev Assoc Med Bras (1992). 2020 May;66(5):615-622. doi: 10.1590/1806-9282.66.5.615. Epub 2020 Jul 3.
OBJECTIVE To explore the association of brain-derived neurotrophic factor gene (BDNF) polymorphism with the latent cognitive endophenotype of posttraumatic stress disorder (PTSD) after major natural disasters in Hainan Province, China. METHODS A total of 300 patients with PTSD and 150 healthy controls (HC) were surveyed by psychoanalysis scale to assess their cognitive functions. Polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE) were used to detect the BDNF gene polymorphism. RESULTS In terms of the cognitive function, the scores in the PTSD group were worse than those of the HC group (P < 0.05 or P < 0.01). There was a significant difference in the distribution of BDNF genotype and allele frequency between the two groups (P < 0.05). PTSD endophenotypes were significantly different among the BDNF genotypes in the PTSD group (P ≤ 0.01). CONCLUSION There is a statistically significant difference in the polymorphism of BDNF gene between PTSD and HC groups, and the alleles are associated with the incidence of PTSD. Thus, it may be a risk factor for PTSD.
目的 探讨中国海南省重大自然灾害后创伤后应激障碍（PTSD）潜在认知内表型与脑源性神经营养因子基因（BDNF）多态性的相关性。方法 采用精神分析量表对300例PTSD患者和150例健康对照（HC）进行调查，以评估其认知功能。采用聚合酶链反应（PCR）和聚丙烯酰胺凝胶电泳（PAGE）检测BDNF基因多态性。结果 在认知功能方面，PTSD组得分低于HC组（P<0.05或P<0.01）。两组间BDNF基因型和等位基因频率分布存在显著差异（P<0.05）。PTSD组中BDNF基因型间的PTSD内表型存在显著差异（P≤0.01）。结论 PTSD组与HC组BDNF基因多态性存在统计学显著差异，且等位基因与PTSD的发生相关。因此，它可能是PTSD的一个危险因素。
